Arthritis/rheumatic disorders:

Indications for Tolmetin 400mg:

Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Treatment of acute flares and the long-term management of the chronic disease. Treatment of juvenile rheumatoid arthritis.


Initially 400mg 3 times daily. Maintenance: 600–1800mg daily in divided doses; max 1800mg/day.


<2yrs: not recommended. ≥2yrs: Initially 20mg/kg/day in divided doses (3–4 times daily). Maintenance: usual dose range: 15–30mg/kg/day; max 30mg/kg/day.


Aspirin allergy. Coronary artery bypass graft surgery.


Advanced renal disease: not recommended. Hypertension; monitor. CHF. Edema. Asthma. History of ulcer disease or GI bleeding. Bleeding disorders. Dehydration. Monitor blood, hepatic, and renal function in chronic use. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. C: <30 weeks gestation; Cat. D: ≥30 weeks gestation: avoid). Nursing mothers: not recommended.

See Also:

Pharmacologic Class:



Avoid aspirin. May antagonize ACE inhibitors, diuretics. Increased risk of GI bleed with oral corticosteroids, anticoagulants (monitor), alcohol, smoking. Methotrexate excretion reduced. Increases lithium levels.

Adverse Reactions:

GI upset, abdominal pain, dyspepsia, flatulence, headache, asthenia, elevated BP, edema, dizziness, weight gain, weight loss; rash (discontinue if occurs), GI ulcer/bleed, elevated liver enzymes (discontinue if hepatotoxicity develops), blood dyscrasias, renal papillary necrosis. See literature re: risk of cardiovascular events.


Formerly known under the brand name Tolectin DS.

How Supplied:

Contact supplier.