Tolmetin 400mg

  • Arthritis/rheumatic disorders

Tolmetin 400mg Generic Name & Formulations

General Description

Tolmetin sodium 400mg; caps; contains sodium 36mg/cap.

Pharmacological Class


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How Supplied

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Tolmetin 400mg Indications


Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Treatment of acute flares and the long-term management of the chronic disease. Treatment of juvenile rheumatoid arthritis.

Tolmetin 400mg Dosage and Administration


Initially 400mg 3 times daily. Maintenance: 600–1800mg daily in divided doses; max 1800mg/day.


<2yrs: not recommended. ≥2yrs: Initially 20mg/kg/day in divided doses (3–4 times daily). Maintenance: usual dose range: 15–30mg/kg/day; max 30mg/kg/day.

Tolmetin 400mg Contraindications


Aspirin allergy. Coronary artery bypass graft surgery.

Tolmetin 400mg Boxed Warnings

Not Applicable

Tolmetin 400mg Warnings/Precautions


Advanced renal disease: not recommended. Hypertension; monitor. CHF. Edema. Asthma. History of ulcer disease or GI bleeding. Bleeding disorders. Dehydration. Monitor blood, hepatic, and renal function in chronic use. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. C: <30 weeks gestation; Cat. D: ≥30 weeks gestation: avoid). Nursing mothers: not recommended.

Tolmetin 400mg Pharmacokinetics

See Literature

Tolmetin 400mg Interactions


Avoid aspirin. May antagonize ACE inhibitors, diuretics. Increased risk of GI bleed with oral corticosteroids, anticoagulants (monitor), alcohol, smoking. Methotrexate excretion reduced. Increases lithium levels.

Tolmetin 400mg Adverse Reactions

Adverse Reactions

GI upset, abdominal pain, dyspepsia, flatulence, headache, asthenia, elevated BP, edema, dizziness, weight gain, weight loss; rash (discontinue if occurs), GI ulcer/bleed, elevated liver enzymes (discontinue if hepatotoxicity develops), blood dyscrasias, renal papillary necrosis. See literature re: risk of cardiovascular events.

Tolmetin 400mg Clinical Trials

See Literature

Tolmetin 400mg Note


Formerly known under the brand name Tolectin DS.

Tolmetin 400mg Patient Counseling

See Literature