• Thromboembolic disorders

Tnkase Generic Name & Formulations

General Description

Tenecteplase 50mg/vial; lyophilized pwd for IV inj after reconstitution.

Pharmacological Class

Tissue plasminogen activator (tPA).

How Supplied

Vial—1 (w. diluent, supplies)


Tnkase Indications


To reduce mortality associated with acute myocardial infarction (AMI).

Tnkase Dosage and Administration


Start treatment soon after onset of AMI symptoms. Give as single IV bolus over 5 seconds. <60kg: 30mg; ≥60kg–<70kg: 35mg; ≥70kg–<80kg: 40mg; ≥80kg–<90kg: 45mg; ≥90kg: 50mg. Max: 50mg.


Not recommended.

Tnkase Contraindications


Active internal bleeding. History of cerebrovascular accident. Intracranial or intraspinal surgery or trauma within 2 months. Intracranial neoplasm, arteriovenous malformation, or aneurysm. Bleeding diathesis. Severe uncontrolled hypertension.

Tnkase Boxed Warnings

Not Applicable

Tnkase Warnings/Precautions


Avoid noncompressible arterial puncture, internal jugular and subclavian venous puncture, IM injections and nonessential handling of patient during treatment. Increased bleeding risk at puncture sites; minimize arterial and venous punctures. Increased risk of complications with recent major surgery, cerebrovascular disease, GI or GU bleeding, recent trauma, hypertension (systolic BP ≥180mm Hg and/or diastolic BP ≥110mm Hg), acute pericarditis, subacute bacterial endocarditis, hemostatic defects, hepatic dysfunction, pregnancy, hemorrhagic ophthalmic conditions, septic thrombophlebitis, elderly. Increased risk of thromboembolic events in those with left heart thrombus (eg, mitral stenosis, A-fib). Pregnancy. Nursing mothers.

Tnkase Pharmacokinetics

See Literature

Tnkase Interactions


Increased bleeding risk with heparin, vitamin K antagonists, aspirin, dipyridamole, GP IIb/IIIa inhibitors. May interfere with coagulation tests.

Tnkase Adverse Reactions

Adverse Reactions

Bleeding (may be serious), cardiogenic shock, arrhythmias, AV block, pulmonary edema, heart failure, cardiac arrest, recurrent MI, myocardial rupture, cardiac tamponade, pericarditis, pericardial effusion, mitral regurgitation, thromboembolism, electromechanical dissociation, nausea, vomiting, hypotension, fever; hypersensitivity reactions (monitor), cholesterol embolism.

Tnkase Clinical Trials

See Literature

Tnkase Note

Not Applicable

Tnkase Patient Counseling

See Literature