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Timoptic Ocudose Generic Name & Formulations
Legal Class
Rx
General Description
Timolol (as maleate) 0.25%, 0.5%; (0.2mL/dose); oph soln; preservative-free.
Pharmacological Class
Noncardioselective beta-blocker.
See Also
How Supplied
Soln—contact supplier; Ocudose—60; XE—2.5mL, 5mL
Manufacturer
Generic Availability
YES
Timoptic Ocudose Indications
Indications
Elevated intraocular pressure in ocular hypertension or open-angle glaucoma.
Timoptic Ocudose Dosage and Administration
Adults and Children
<2yrs: not established. ≥2yrs: Initially 1 drop of 0.25% twice daily; max 1 drop of 0.5% twice daily. Transfer from other drugs, see full labeling.
Timoptic Ocudose Contraindications
Contraindications
Greater than 1st-degree AV block. Uncompensated cardiac failure. Cardiogenic shock. Sinus bradycardia. History of bronchospasm. Bronchial asthma. Severe COPD.
Timoptic Ocudose Boxed Warnings
Not Applicable
Timoptic Ocudose Warnings/Precautions
Warnings/Precautions
Not for use as sole agent in angle-closure glaucoma. Poor cardiac reserve should be controlled with digitalis and diuretics. Diabetes. Presbyopia. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Measure intraocular pressure after 4 weeks of treatment. Avoid abrupt cessation. Discontinue at 1st sign of cardiac failure and before surgery. Pregnancy. Nursing mothers: not recommended.
Timoptic Ocudose Pharmacokinetics
See Literature
Timoptic Ocudose Interactions
Interactions
May potentiate systemic β-blockers, reserpine, hypoglycemics and mydriatic effect of topical epinephrine. Additive cardiac and pulmonary effects with anticholinesterase miotics. May antagonize bronchodilation from β-adrenergic agonists. May cause conduction defects with calcium channel blockers, digoxin. May be potentiated by CYP2D6 inhibitors (eg, quinidine, SSRIs).
Timoptic Ocudose Adverse Reactions
Adverse Reactions
Ocular irritation, sensitization, rash, dizziness, blurred vision, corneal anesthesia, headache, GI upset, paresthesias. Systemic β-blocker effects (bradycardia, arrhythmias, hypotension, bronchospasm, heart failure). Aphakic maculopathy (rare).
Timoptic Ocudose Clinical Trials
See Literature
Timoptic Ocudose Note
Not Applicable
Timoptic Ocudose Patient Counseling
See Literature
