Timolol Maleate

  • Glaucoma

Timolol Maleate Generic Name & Formulations

General Description

Timolol (as maleate) 0.25%, 0.5%; oph soln; contains benzalkonium chloride.

Pharmacological Class

Noncardioselective beta-blocker.

How Supplied

Soln—contact supplier; Ocudose—60; XE—2.5mL, 5mL

Generic Availability


Timolol Maleate Indications


Elevated intraocular pressure in ocular hypertension or open-angle glaucoma.

Timolol Maleate Dosage and Administration

Adults and Children

<2yrs: not established. ≥2yrs: Initially 1 drop of 0.25% twice daily; max 1 drop of 0.5% twice daily. Transfer from other drugs, see full labeling.

Timolol Maleate Contraindications


Greater than 1st-degree AV block. Uncompensated cardiac failure. Cardiogenic shock. Sinus bradycardia. History of bronchospasm. Bronchial asthma. Severe COPD.

Timolol Maleate Boxed Warnings

Not Applicable

Timolol Maleate Warnings/Precautions


Not for use as sole agent in angle-closure glaucoma. Poor cardiac reserve should be controlled with digitalis and diuretics. Diabetes. Presbyopia. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Measure intraocular pressure after 4 weeks of treatment. Avoid abrupt cessation. Discontinue at 1st sign of cardiac failure and before surgery. Pregnancy. Nursing mothers: not recommended.

Timolol Maleate Pharmacokinetics

See Literature

Timolol Maleate Interactions


May potentiate systemic β-blockers, reserpine, hypoglycemics and mydriatic effect of topical epinephrine. Additive cardiac and pulmonary effects with anticholinesterase miotics. May antagonize bronchodilation from β-adrenergic agonists. May cause conduction defects with calcium channel blockers, digoxin. May be potentiated by CYP2D6 inhibitors (eg, quinidine, SSRIs).

Timolol Maleate Adverse Reactions

Adverse Reactions

Ocular irritation, sensitization, rash, dizziness, blurred vision, corneal anesthesia, headache, GI upset, paresthesias. Systemic β-blocker effects (bradycardia, arrhythmias, hypotension, bronchospasm, heart failure). Aphakic maculopathy (rare).

Timolol Maleate Clinical Trials

See Literature

Timolol Maleate Note


Formerly known under the brand name Timoptic.

Timolol Maleate Patient Counseling

See Literature