Tice Bcg

  • Bladder, kidney, and other urologic cancers

Tice Bcg Generic Name & Formulations

General Description

Bacillus of Calmette and Guerin (BCG) strain of Mycobacterium bovis live, attenuated culture preparation; 50mg per vial; pwd for intravesical administration after reconstitution and dilution; preservative-free.

Pharmacological Class

BCG Live.

How Supplied



Mechanism of Action

Tice BCG induces a granulomatous reaction at the local site of administration. The precise mechanism of action is unknown.

Tice Bcg Indications


Treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder. Prophylaxis of stage Ta and/or T1 papillary tumors following transurethral resection (TUR).

Tice Bcg Dosage and Administration


1 vial in 50mL preservative-free saline intravesically once per week for 6 weeks (may repeat this regimen once if remission not achieved); then monthly for 6–12 months if needed. Avoid fluid at least 4hrs before treatment and void immediately before administration. Retain in bladder for 2hrs.


Not recommended.

Tice Bcg Contraindications


Immunosuppressed. Active TB. Febrile illness. UTI. Gross hematuria. Do not give within 7 days after bladder biopsy, TUR, or traumatic catheterization.

Tice Bcg Boxed Warnings

Boxed Warning

Prepare, handle, and dispose of as a biohazard material. BCG infections. Nosocomial infections.

Tice Bcg Warnings/Precautions


Not a vaccine for prevention of cancer or TB. Not for IV or SC inj use. Determine PPD status prior to therapy; rule out active TB if (+). Monitor for signs of systemic BCG infection: flu-like symptoms >72 hrs, fever ≥103°F, persistent LFT abnormalities; prostatitis, epididymitis, orchitis >2 days; treat with at least 2 antimycobacterial drugs (except pyrazinamide). High risk for HIV infection. Local irritative toxicities: do not treat with antimycobacterials. Bleeding bladder mucosa, small bladder. Disinfect fluid voided after therapy with bleach. PPD seroconversion may occur with treatment. Pregnancy, nursing mothers: not recommended.

Tice Bcg Pharmacokinetics

See Literature

Tice Bcg Interactions


Immunosuppressants, myelosuppressants, radiation, antimicrobial therapy may reduce efficacy.

Tice Bcg Adverse Reactions

Adverse Reactions

Dysuria, urinary frequency, urgency, flu-like syndrome, hematuria, fever, malaise/fatigue, cystitis, bladder irritation, inflammation (begins after 4 hrs and last up to 72 hrs), chills, systemic BCG infection, nocturia, cramps, pain, incontinence, rigors, arthralgia.

Tice Bcg Clinical Trials

See Literature

Tice Bcg Note

Not Applicable

Tice Bcg Patient Counseling

See Literature