Select therapeutic use:

Angina:

Indications for TIAZAC:

Chronic stable angina.

Adult Dosage:

May sprinkle contents on applesauce; do not crush or chew contents. Initially 120–180mg once daily; adjust at 1–2 week intervals; usual max 540mg/day.

Children Dosage:

Not recommended.

TIAZAC Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Severe hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

TIAZAC Warnings/Precautions:

Heart failure. Hypotension. Impaired renal or hepatic function. Monitor liver function. Discontinue if persistent rash occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.

TIAZAC Classification:

Calcium channel blocker (CCB) (benzothiazepine).

TIAZAC Interactions:

Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, ivabradine (avoid), simvastatin (limit simvastatin dose to 10mg/day), quinidine; consider dose adjustments; monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.

Adverse Reactions:

Headache, pain, dizziness, edema, asthenia, bradycardia, dyspepsia, dyspnea, bronchitis, AV block; CHF, liver abnormalities (rare).

Generic Drug Availability:

YES

How Supplied:

Caps—30, 90, 1000

Pricing for TIAZAC

240mg capsule (Qty: 90)
Appx. price $41
GoodRx

Hypertension:

Indications for TIAZAC:

Hypertension.

Adult Dosage:

May sprinkle contents on applesauce; do not crush or chew contents. Initially 120–240mg once daily; adjust at 2-week intervals; usual max 540mg/day.

Children Dosage:

Not recommended.

TIAZAC Contraindications:

Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Severe hypotension. Acute MI and pulmonary congestion documented by X-ray on admission.

TIAZAC Warnings/Precautions:

Heart failure. Impaired renal or hepatic function. Monitor liver function. Discontinue if persistent rash occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.

TIAZAC Classification:

Calcium channel blocker (CCB) (benzothiazepine).

TIAZAC Interactions:

Caution with digoxin, β-blockers, others that may affect cardiac conduction (may lead to AV block). Monitor heart rate with concomitant clonidine. Potentiates propranolol, benzodiazepines, buspirone, cyclosporine, carbamazepine, ivabradine (avoid), simvastatin (limit simvastatin dose to 10mg/day), quinidine; consider dose adjustments; monitor. Caution with CYP3A4 substrates, inhibitors (eg, cimetidine), or inducers (eg, rifampin). Anesthetics may potentiate cardiac depression.

Adverse Reactions:

Edema, headache, dizziness, asthenia, 1st-degree AV block, bradycardia, flushing, nausea, rash; CHF, liver abnormalities (rare).

Generic Drug Availability:

YES

How Supplied:

Caps—30, 90, 1000

Pricing for TIAZAC

240mg capsule (Qty: 90)
Appx. price $41
GoodRx