Thrombate Iii

  • Miscellaneous hematological agents

Thrombate Iii Generic Name & Formulations

General Description

Antithrombin III (human) 500 IU, 1000 IU; per vial; lyophilized pwd for IV infusion after reconstitution; preservative-free.

Pharmacological Class

Thrombin inhibitor (α2-glycoprotein).

How Supplied

Single-use vial—1 (w. diluent, needles)

Thrombate Iii Indications


Treatment of patients with hereditary antithrombin III deficiency (AT-III) in surgical or obstetrical procedures and thromboembolism.

Thrombate Iii Dosage and Administration


Give by IV infusion over 10–20 minutes. Individualized. Dose (units required)= [desired (% of normal) – baseline (% of normal) AT-III level] X weight (kg)/1.4. Loading dose: increase AT-III to 120% of normal. Subsequent dose should be based on AT-III levels obtained 20 minutes post-infusion, every 12hrs, and before the next dose. Maintain AT-III levels at 80–120% of normal for 2–8 days.


Not recommended.

Thrombate Iii Contraindications

Not Applicable

Thrombate Iii Boxed Warnings

Not Applicable

Thrombate Iii Warnings/Precautions


Surgery. Hemorrhage. Acute thrombosis. Monitor AT-III levels during treatment. Contains human plasma; monitor for possible infection transmission. Pregnancy (Cat.B).

Thrombate Iii Pharmacokinetics

See Literature

Thrombate Iii Interactions


Potentiates anticoagulant effect of heparin; reduce heparin dose.

Thrombate Iii Adverse Reactions

Adverse Reactions

Dizziness, chest tightness, nausea, taste disturbances, chills, cramps, shortness of breath, chest pain, light-headedness, bowel fullness, hives, fever, hematoma formation.

Thrombate Iii Clinical Trials

See Literature

Thrombate Iii Note


Report all infections suspected to be transmitted by Thrombate III to (800) 520-2807.

Thrombate Iii Patient Counseling

See Literature