• Asthma/COPD

Theo-24 Generic Name & Formulations

General Description

Theophylline 100mg, 200mg, 300mg, 400mg; ext-rel caps.

Pharmacological Class


How Supplied

Caps 100mg, 400mg—100; 200mg, 300mg—100, 500


Theo-24 Indications


Asthma. Chronic bronchitis. Emphysema.

Theo-24 Dosage and Administration


See literature. Swallow whole. Stabilized patients may be switched from immediate-release or controlled-release product to once- or twice-daily dosing with Theo-24 on a mg/mg basis. Do not take within 1 hour of fatty food if on high dose. Max without serum level monitoring: 12–15years: 16mg/kg (max 400mg) per day; ≥16years: 400mg/day.


Not recommended.

Theo-24 Contraindications

Not Applicable

Theo-24 Boxed Warnings

Not Applicable

Theo-24 Warnings/Precautions


Not for primary treatment of acute attack. Active peptic ulcer. Arrhythmias. Seizure disorders. Hepatic dysfunction. CHF. Acute pulmonary edema. Cor pulmonale. Hypothyroidism. Fever. Sepsis. Shock. Monitor serum levels; do not try to maintain non-tolerated doses. Rapid metabolizers. Infants (<3 months of age) with reduced renal function. Neonates. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Theo-24 Pharmacokinetics

See Literature

Theo-24 Interactions


See literature. Smokers have increased metabolism. Potentiated by quinolones, macrolides, enoxacin, cimetidine, alcohol, allopurinol, estrogen oral contraceptives, tacrine, interferon alpha, disulfiram, fluvoxamine, verapamil, mexiletine, methotrexate, pentoxifylline, propafenone, ticlopidine, thiabenazole. Antagonized by phenytoin, rifampin, barbiturates, carbamazepine, aminogluthethimide, moricizine, St. John's wort, isoproterenol, sulfinpyrazone. Avoid β-blockers. Antagonizes lithium, benzodiazepines, pancuronium, adenosine. Toxicity with sympathomimetics. Seizures with ketamine. Arrhythmias with halothane.

Theo-24 Adverse Reactions

Adverse Reactions

GI upset, headache, CNS stimulation, diuresis, arrhythmias, seizures.

Theo-24 Clinical Trials

See Literature

Theo-24 Note

Not Applicable

Theo-24 Patient Counseling

See Literature