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Teriparatide Injection Generic Name & Formulations
Legal Class
Rx
General Description
Teriparatide (recombinant) 250mcg/mL; soln for SC inj; contains m-cresol.
Pharmacological Class
Hormone (human parathyroid hormone, recombinant).
How Supplied
Single-patient-use pens (2.48mL)—1
Manufacturer
Teriparatide Injection Indications
Indications
Postmenopausal osteoporosis in women who are at high risk for fracture. To increase bone mass in men with primary or hypogonadal osteoporosis who are at high risk for fracture. Treatment of men and women with osteoporosis associated with sustained glucocorticoid therapy at high risk for fracture (see full labeling).
Teriparatide Injection Dosage and Administration
Adult
20mcg SC once daily into thigh or abdominal wall; may treat for up to 2 years.
Children
Not established.
Teriparatide Injection Contraindications
Not Applicable
Teriparatide Injection Boxed Warnings
Boxed Warning
Potential risk of osteosarcoma.
Teriparatide Injection Warnings/Precautions
Warnings/Precautions
Increased baseline risk for osteosarcoma (eg, Paget's disease of bone, unexplained increased alkaline phosphatase, open epiphyses, prior skeletal radiation therapy), bone metastases, history of skeletal malignancies, metabolic bone disease, hypercalcemia or risk thereof (eg, hyperparathyroidism): not recommended. Urolithiasis. Hypercalciuria. Hepatic, renal, or cardiac disease. Pregnancy. Nursing mothers: not recommended.
Teriparatide Injection Pharmacokinetics
See Literature
Teriparatide Injection Interactions
Interactions
Caution with digoxin (teriparatide-induced hypercalcemia increases risk of toxicity).
Teriparatide Injection Adverse Reactions
Adverse Reactions
Arthralgia, pain, nausea; transient orthostatic hypotension, hypercalcemia, hyperuricemia, inj site reactions.
Teriparatide Injection Clinical Trials
See Literature
Teriparatide Injection Note
Not Applicable
Teriparatide Injection Patient Counseling
See Literature
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