• Hypertension

Tenoretic Generic Name & Formulations

General Description

Atenolol, chlorthalidone; 50mg/25mg+, 100mg/25mg; tabs; (+) scored.

Pharmacological Class

Cardioselective beta-blocker + diuretic.

How Supplied


Tenoretic Indications



Tenoretic Dosage and Administration


Switching from monotherapy: initially one 50mg/25mg tab daily; may increase to one 100mg/25mg tab daily. CrCl 15–35mL/minute: max 50mg atenolol/day. CrCl <15mL/minute: max 50mg atenolol every other day.


Not recommended.

Tenoretic Contraindications


Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. Anuria. Sulfonamide allergy. Pregnancy (Cat.D).

Tenoretic Boxed Warnings

Not Applicable

Tenoretic Warnings/Precautions


Heart failure. Bronchospastic disease. Renal or hepatic dysfunction. SLE. Gout. Diabetes. Asthma. Hyperthyroidism. Hypokalemia. Surgery. Postsympathectomy. Peripheral circulatory disorders. Avoid abrupt cessation. Monitor electrolytes. Excessive diuresis. Potassium supplementation may be needed. Nursing mothers: not recommended.

Tenoretic Pharmacokinetics

See Literature

Tenoretic Interactions


May potentiate hypotension with prazosin, alcohol, catecholamine-depleting drugs, CNS depressants. May increase toxicity of diazoxide, digitalis, lithium. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Adjust antidiabetic medications. Increased rebound hypertension with clonidine withdrawal. May block epinephrine. May increase responsiveness to tubocurarine. ACTH, steroids, amphotericin B increase risk of hypokalemia.

Tenoretic Adverse Reactions

Adverse Reactions

Heart failure, bronchospasm, bradycardia, heart block, dizziness, fatigue, fluid or electrolyte imbalance, hyperuricemia, orthostatic hypotension, GI upset, cold extremities.

Tenoretic Clinical Trials

See Literature

Tenoretic Note

Not Applicable

Tenoretic Patient Counseling

See Literature