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Tekturna Hct Generic Name & Formulations
Legal Class
Rx
General Description
Aliskiren, hydrochlorothiazide; 150mg/12.5mg, 150mg/25mg, 300mg/12.5mg, 300mg/25mg; tabs.
Pharmacological Class
Direct renin inhibitor + diuretic (thiazide).
How Supplied
Tabs—30, 90
Manufacturer
Generic Availability
NO
Tekturna Hct Indications
Indications
Hypertension.
Tekturna Hct Dosage and Administration
Adult
Take consistently with regard to meals. ≥18yrs: 1 tab once daily. Add-on or initial therapy and not volume-depleted: initially 150mg/12.5mg; may increase after 2–4 weeks up to max 300mg/25mg. Replacement therapy: may be substituted for the titrated components. Maximum effect usually seen at 4 weeks.
Children
<18yrs: not established.
Tekturna Hct Contraindications
Contraindications
Concomitant ARBs or ACEIs in diabetes. Anuria. Sulfonamide allergy.
Tekturna Hct Boxed Warnings
Boxed Warning
Fetal toxicity.
Tekturna Hct Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting therapy or start under close supervision. Discontinue if angioedema or laryngeal edema occurs (have SC epinephrine available). Moderate renal impairment (CrCl <60mL/min): avoid concomitant ARBs or ACEIs. Monitor BP, electrolytes, and renal function periodically. Consider withholding or discontinuing if significant renal dysfunction develops. Renal artery stenosis. Severe HF. Post-MI. Diabetes. Hepatic dysfunction. Asthma. SLE. Gout. Acute myopia. Secondary acute angle-closure glaucoma. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.
Tekturna Hct Pharmacokinetics
See Literature
Tekturna Hct Interactions
Interactions
Avoid concomitant cyclosporine, itraconazole. Caution with NSAIDs, K+ supplements, K+ sparing diuretics, K+ containing salt substitutes; may cause hyperkalemia. Potentiates antihypertensives, possibly non-depolarizing muscle relaxants. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. Dual inhibition of the renin-angiotensin system with ARBs or ACEIs may increase risk of hypotension, hyperkalemia, renal function changes. Concomitant furosemide; monitor. Adjust antidiabetic drugs. Concomitant lithium (risk of toxicity): monitor. Orthostatic hypotension potentiated by alcohol, CNS depressants. Decreased absorption by cholestyramine, colestipol resins (separate dosing by at least 4hrs), high fat meals.
Tekturna Hct Adverse Reactions
Adverse Reactions
Dizziness, flu-like symptoms, diarrhea, cough, vertigo, asthenia, arthralgia, elevated BUN/creatinine, ALT, cholesterol, uric acid; rare: angioedema. HCTZ: increased risk for non-melanoma skin cancer.
Tekturna Hct Clinical Trials
See Literature
Tekturna Hct Note
Not Applicable
Tekturna Hct Patient Counseling
See Literature
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