Targretin Gel

  • Leukemias, lymphomas, and other hematologic cancers

Targretin Gel Generic Name & Formulations

General Description

Bexarotene 1%; gel.

Pharmacological Class


How Supplied


Targretin Gel Indications


Cutaneous lesions in patients with CTCL (Stage IA and IB) who have refractory or persistent disease after other therapies or who have not tolerated other therapies.

Targretin Gel Dosage and Administration


Apply once every other day for the 1st week; then increase frequency at weekly intervals to once daily, then twice daily, then 3 times daily, then 4 times daily based on lesion tolerance. Usual dosing frequency: 2–4 times daily; may reduce if application site toxicity occurs. Allow gel to dry. Do not occlude.


Not established.

Targretin Gel Contraindications



Targretin Gel Boxed Warnings

Not Applicable

Targretin Gel Warnings/Precautions


Be fully familiar with this drug's toxicity before use. Counsel patients monthly about need for contraception. Females of reproductive potential: obtain reliable negative pregnancy test within 1 week of start; repeat monthly. Start therapy on 2nd or 3rd day of normal menstrual period. Use two effective forms of contraception 1 month prior to, during, and for 1 month after therapy. Max 1 month/℞. Males with partners who are or may become pregnant: use condoms during and for at least 1 month after therapy. Hepatic or renal impairment. Discontinue temporarily if severe irritation occurs. Avoid sun, UV light, and mucosal membranes. Nursing mothers: not recommended.

Targretin Gel Pharmacokinetics

See Literature

Targretin Gel Interactions


Avoid concomitant products that contain DEET. May be potentiated by CYP3A4 inhibitors (eg, ketoconazole, itraconazole, erythromycin, grapefruit juice). Caution with gemfibrozil. Limit Vit. A supplements to avoid toxicity.

Targretin Gel Adverse Reactions

Adverse Reactions

Application site reactions (eg, rash, pruritus, skin disorders, pain, contact dermatitis).

Targretin Gel Clinical Trials

See Literature

Targretin Gel Note

Not Applicable

Targretin Gel Patient Counseling

See Literature