Targretin Gel Generic Name & Formulations
Bexarotene 1%; gel.
Targretin Gel Indications
Cutaneous lesions in patients with CTCL (Stage IA and IB) who have refractory or persistent disease after other therapies or who have not tolerated other therapies.
Targretin Gel Dosage and Administration
Apply once every other day for the 1st week; then increase frequency at weekly intervals to once daily, then twice daily, then 3 times daily, then 4 times daily based on lesion tolerance. Usual dosing frequency: 2–4 times daily; may reduce if application site toxicity occurs. Allow gel to dry. Do not occlude.
Targretin Gel Contraindications
Targretin Gel Boxed Warnings
Targretin Gel Warnings/Precautions
Be fully familiar with this drug's toxicity before use. Counsel patients monthly about need for contraception. Females of reproductive potential: obtain reliable negative pregnancy test within 1 week of start; repeat monthly. Start therapy on 2nd or 3rd day of normal menstrual period. Use two effective forms of contraception 1 month prior to, during, and for 1 month after therapy. Max 1 month/℞. Males with partners who are or may become pregnant: use condoms during and for at least 1 month after therapy. Hepatic or renal impairment. Discontinue temporarily if severe irritation occurs. Avoid sun, UV light, and mucosal membranes. Nursing mothers: not recommended.
Targretin Gel Pharmacokinetics
Targretin Gel Interactions
Avoid concomitant products that contain DEET. May be potentiated by CYP3A4 inhibitors (eg, ketoconazole, itraconazole, erythromycin, grapefruit juice). Caution with gemfibrozil. Limit Vit. A supplements to avoid toxicity.
Targretin Gel Adverse Reactions
Application site reactions (eg, rash, pruritus, skin disorders, pain, contact dermatitis).
Targretin Gel Clinical Trials
Targretin Gel Note
Targretin Gel Patient Counseling