Synvisc One Generic Name & Formulations
Hylan G-F 20 (hylan A and hylan B) 48mg; per 6mL; soln for intra-articular inj.
Synvisc One Indications
Treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics (eg, acetaminophen).
Synvisc One Dosage and Administration
Remove synovial fluid or effusion before inj. Give as a single intra-articular inj. 6mL in one knee only.
Synvisc One Contraindications
Knee joint infections. Skin diseases or infections in area of the inj site.
Synvisc One Boxed Warnings
Synvisc One Warnings/Precautions
Avian protein, feathers, or egg allergy. Severely inflamed knee joints. Lymphatic or venous stasis in leg. Advise patients to avoid strenuous activities for approx. 48 hrs following inj. Pregnancy, nursing mothers: not established.
Synvisc One Pharmacokinetics
Synvisc One Interactions
Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not studied.
Synvisc One Adverse Reactions
Arthralgia, arthritis, arthropathy, inj site pain, gait disturbance; joint effusion, stiffness, swelling, warmth, pain.
Synvisc One Clinical Trials
Synvisc One Note
Synvisc One Patient Counseling