Synvisc One

  • Arthritis/rheumatic disorders

Synvisc One Generic Name & Formulations

General Description

Hylan G-F 20 (hylan A and hylan B) 48mg; per 6mL; soln for intra-articular inj.

Pharmacological Class

Hyaluronan derivative.

How Supplied

Single-use syringe—1


Generic Availability


Synvisc One Indications


Treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics (eg, acetaminophen).

Synvisc One Dosage and Administration


Remove synovial fluid or effusion before inj. Give as a single intra-articular inj. 6mL in one knee only.


Not recommended.

Synvisc One Contraindications


Knee joint infections. Skin diseases or infections in area of the inj site.

Synvisc One Boxed Warnings

Not Applicable

Synvisc One Warnings/Precautions


Avian protein, feathers, or egg allergy. Severely inflamed knee joints. Lymphatic or venous stasis in leg. Advise patients to avoid strenuous activities for approx. 48 hrs following inj. Pregnancy, nursing mothers: not established.

Synvisc One Pharmacokinetics

See Literature

Synvisc One Interactions


Avoid use of disinfectants containing quaternary ammonium salts; hyaluronan can precipitate in their presence. Concomitant other intra-articular inj: not studied.

Synvisc One Adverse Reactions

Adverse Reactions

Arthralgia, arthritis, arthropathy, inj site pain, gait disturbance; joint effusion, stiffness, swelling, warmth, pain.

Synvisc One Clinical Trials

See Literature

Synvisc One Note

Not Applicable

Synvisc One Patient Counseling

See Literature