• Topical pain relief

Synera Generic Name & Formulations

General Description

Lidocaine 70mg, tetracaine 70mg; topical patch.

Pharmacological Class

Topical anesthetic.

How Supplied

Patches—1, 10


Generic Availability


Synera Indications


For local dermal analgesia for superficial venous access and superficial dermatological procedures (eg, excision, electrodessication, shave biopsy of skin lesions).

Synera Dosage and Administration

Adults and Children

<3yrs: see full labeling. Apply to intact skin. ≥3yrs: Prior to venipuncture or IV cannulation: apply for 20–30mins. Superficial dermatological procedures (eg, excision, shave biopsy): apply for 30mins prior to procedure. Remove patch if irritation or burning sensation occurs. Do not cut patches or remove top cover (may cause thermal injury). Do not cover holes on top side of patch.

Synera Contraindications

Not Applicable

Synera Boxed Warnings

Not Applicable

Synera Warnings/Precautions


Risk of methemoglobinemia (esp. in G6PD deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6 months of age, concurrent exposure to oxidizing agents or metabolites); monitor. Avoid simultaneous or sequential application or for longer than recommended. Remove before undergoing MRI (contains iron powder). Avoid eyes, mucous membranes, broken or inflamed skin, inadvertent trauma (eg, scratching, rubbing, exposure to extreme temperatures). Effect on intradermal live vaccines undetermined. Severe hepatic disease or pseudocholinesterase deficiency. Acutely ill or debilitated. Elderly. Pregnancy. Nursing mothers: avoid direct infant exposure.

Synera Pharmacokinetics

See Literature

Synera Interactions


Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, others. Toxicity may be potentiated by Class I antiarrhythmics (eg, tocainide, mexiletine). Additive effects with other products containing local anesthetics.

Synera Adverse Reactions

Adverse Reactions

Local reactions (eg, erythema, blanching, edema), anaphylactoid reactions.

Synera Clinical Trials

See Literature

Synera Note

Not Applicable

Synera Patient Counseling

See Literature