Sulfamylon Cream

  • Skin infections (topicals)

Sulfamylon Cream Generic Name & Formulations

General Description

Mafenide acetate 85mg (base); crm; contains parabens, sodium metabisulfite.

Pharmacological Class


How Supplied

Crm—2oz, 4oz, 16oz


Sulfamylon Cream Indications


Adjunct in 2nd and 3rd degree burns.

Sulfamylon Cream Dosage and Administration

Adults and Children

Apply 1–2 times daily aseptically with approximately 1/16 inch depth to cleansed and debrided burns. Ensure coverage of burned areas at all times; reapply promptly if removed. May be occluded with a thin layer of dressing, if needed. Continue until wound is healed or site is ready for grafting. Withhold therapy for 24–48 hours if acidosis occurs.

Sulfamylon Cream Contraindications


Sulfonamide allergy.

Sulfamylon Cream Boxed Warnings

Not Applicable

Sulfamylon Cream Warnings/Precautions


G6PD deficiency. Sulfite sensitivity. Asthma. Acute renal failure. Monitor acid-base balance closely (esp. with extensive 2nd degree or partial thickness burns, pulmonary or renal impairment). Pregnancy (Cat.C); (crm: not recommended for women of childbearing potential; unless burn area >20% of total body surface). Nursing mothers: not recommended.

Sulfamylon Cream Pharmacokinetics

See Literature

Sulfamylon Cream Interactions

Sulfamylon Cream Adverse Reactions

Adverse Reactions

Application-site pain, burning sensation, allergic manifestations (eg, rash, pruritus, facial edema, swelling, erythema; discontinue if occur), tachypnea, hyperventilation, metabolic acidosis; respiratory alkalosis, fatal hemolytic anemia with disseminated intravascular coagulation, fungal colonization; rare: excoriation of new skin, bleeding of skin.

Sulfamylon Cream Clinical Trials

See Literature

Sulfamylon Cream Note

Not Applicable

Sulfamylon Cream Patient Counseling

See Literature