Skin infections (topicals):


Adjunct to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Adults and Children:

<3months: not recommended. ≥3months: Cover grafted area with one layer of fine mesh gauze. Cut an eight-ply burn dressing to the size of graft, wet with solution using an irrigation syringe and/or tubing until noticeable leaking. Maintain moisture with irrigation tubing (see literature) or wet dressing every 6–8 hours as needed. May leave wound dressings undisturbed for up to 5 days, except when irrigating. Additional soaks may be initiated until graft take is complete. Continue treatment until autograft vascularization and healing is progressing (approx. 5 days). Individual grafting procedure: max 5 days. Withhold therapy for 24–48 hours if acidosis occurs.


Sulfonamide allergy.


G6PD deficiency. Sulfite sensitivity. Asthma. Acute renal failure. Monitor acid-base balance closely (esp. with extensive 2nd degree or partial thickness burns, pulmonary or renal impairment). Pregnancy (Cat.C); (crm: not recommended for women of childbearing potential; unless burn area >20% of total body surface). Nursing mothers: not recommended.

See Also:

Pharmacologic Class:


Adverse Reactions:

Application-site pain, burning sensation, allergic manifestations (eg, rash, pruritus, facial edema, swelling, erythema; discontinue if occur), tachypnea, hyperventilation, metabolic acidosis; respiratory alkalosis, fatal hemolytic anemia with disseminated intravascular coagulation, fungal colonization; rare: excoriation of new skin, bleeding of skin.

How Supplied:

Crm—2oz, 4oz, 16oz