• Bacterial infections

Sulfadiazine Generic Name & Formulations

General Description

Sulfadiazine 500mg; tabs.

Pharmacological Class

Sulfonamide antibiotic.

How Supplied

Tabs—100, 1000


Sulfadiazine Indications


Susceptible infections including chancroid, trachoma, inclusion conjunctivitis, nocardiosis, UTI (secondary therapy), toxoplasmosis encephalitis, meningococcal meningitis, acute otitis media, rheumatic fever.

Sulfadiazine Dosage and Administration


Initially 2–4g. Maintenance: 2–4g divided into 3–6 doses every 24 hours.


<2 months: see Contraindications. ≥2months: Initially ½ the 24-hour dose. Maintenance: 150mg/kg divided into 4–6 doses every 24 hours, max 6g/24hrs. Rheumatic fever prophylaxis: <30kg: 500mg every 24 hours; >30kg: 1g every 24 hours.

Sulfadiazine Contraindications


Infants <2 months of age (except as adjunctive therapy with pyrimethamine in the treatment of congenital toxoplasmosis). Pregnancy at term. Nursing mothers.

Sulfadiazine Boxed Warnings

Not Applicable

Sulfadiazine Warnings/Precautions


Do not use to treat group A betahemolytic streptococcal infections. Renal or hepatic impairment. Bronchial asthma. Severe allergy. G6PD deficiency. Maintain adequate hydration. Obtain CBCs and urinalyses frequently during therapy. Pregnancy (Cat.C).

Sulfadiazine Pharmacokinetics

See Literature

Sulfadiazine Interactions


May be potentiated by indomethacin, probenecid, salicylates. May potentiate oral anticoagulants, methotrexate, sulfonylureas, thiazide diuretics, uricosuric agents.

Sulfadiazine Adverse Reactions

Adverse Reactions

Blood dyscrasias, allergic reactions, GI upset, hepatitis, pancreatitis, stomatitis, headache, peripheral neuritis, depression, convulsions, ataxia, hallucinations, tinnitus, vertigo, insomnia, crystalluria, stone formation, toxic nephrosis, oliguria, anuria; rare: goiter production, diuresis, hypoglycemia.

Sulfadiazine Clinical Trials

See Literature

Sulfadiazine Note

Not Applicable

Sulfadiazine Patient Counseling

See Literature