• Constipation and bowel cleansers

Suflave Generic Name & Formulations

General Description

Polyethylene glycol 3350 178.7g, sodium sulfate 7.3g, potassium chloride 1.12g, magnesium sulfate 0.9g, sodium chloride 0.5g; per liter; pwd for reconstitution; lemon-lime flavor.

Pharmacological Class

Osmotic laxative.

How Supplied

Bottles (1L)—2 (w. 2 flavor enhancing pkts)

Generic Availability


Mechanism of Action

The primary mode of action is the osmotic effects of polyethylene glycol 3350, sodium sulfate and magnesium sulfate, which induce a laxative effect. The physiological consequence is increased water retention in the lumen of the colon, resulting in loose stools. 

Suflave Indications


Bowel cleansing before colonoscopy. 

Suflave Dosage and Administration


See full labeling. Split-dose regimen: Dose 1 (start the evening before colonoscopy): 1 bottle with flavor enhancing packet. Drink 8oz soln every 15mins until empty; drink additional 16oz water during the PM; Dose 2 (start next morning and no sooner than 4hrs from starting Dose 1): repeat 2nd bottle with flavor enhancing packet. Drink additional 16oz water during the AM. Stop drinking liquids at least 2hrs prior to colonoscopy. May interrupt or reduce rate if GI disturbances occur.


Not established.

Suflave Contraindications


GI obstruction or ileus. Bowel perforation. Toxic colitis or megacolon. Gastric retention.

Suflave Boxed Warnings

Not Applicable

Suflave Warnings/Precautions

Not Applicable

Suflave Pharmacokinetics

See Literature

Suflave Interactions


Do not mix or reconstitute with starch-based thickeners. Caution with drugs that may increase risk for fluid or electrolyte abnormalities, arrhythmias, or QT prolongation. Caution with concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, hyponatremia: may increase risk of seizures. Administer oral medications at least 1hr before starting each dose of Suflave. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and pencillamine at least 2hrs before and not less than 6hrs after Suflave to avoid chelation with magnesium. Avoid concomitant stimulant laxatives (eg, bisacodyl, sodium picosulfate).

Suflave Adverse Reactions

Adverse Reactions

Nausea, abdominal distension, vomiting, abdominal pain, headache; fluid and electrolyte abnormalities, seizures, arrhythmias, renal impairment, aspiration, mucosal ulcerations and ischemic colitis, hypersensitivity reactions. 

Suflave Clinical Trials

See Literature

Suflave Note

Not Applicable

Suflave Patient Counseling

See Literature