Stiolto Respimat

  • Asthma/COPD

Stiolto Respimat Generic Name & Formulations

General Description

Tiotropium 2.5mcg, olodaterol 2.5mcg; per actuation; inhalation spray; contains benzalkonium chloride.

Pharmacological Class

Anticholinergic + long-acting beta-2 agonist (LABA).

How Supplied

Inhaler (w. cartridge)—4g (60 inh)

Generic Availability


Stiolto Respimat Indications


Long-term maintenance treatment of COPD, including chronic bronchitis and/or emphysema.

Limitations of Use

Not indicated to treat acute deteriorations of COPD or for treatment of asthma.

Stiolto Respimat Dosage and Administration


Take at same time each day. 2 inhalations once daily; max 2 inhalations/24hrs.


Not established.

Stiolto Respimat Contraindications


Use of LABA without inhaled corticosteroid (ICS) in asthma.

Stiolto Respimat Boxed Warnings

Not Applicable

Stiolto Respimat Warnings/Precautions


LABA as monotherapy (without ICS) for asthma can increase risk of asthma-related events. Do not initiate in acute deteriorating COPD. Not for relief of acute symptoms. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue if paradoxical bronchospasm or hypersensitivity reactions occur; use alternative therapy. Cardiovascular disease (esp. coronary insufficiency, arrhythmias, hypertrophic obstructive cardiomyopathy, hypertension). Convulsive disorders. Thyrotoxicosis. Prolongation of the QT interval. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Narrow-angle glaucoma. Monitor for signs/symptoms of prostatic hyperplasia, GI or GU obstruction. Risk of hypokalemia or hyperglycemia. Moderate to severe renal impairment: monitor for anticholinergic effects. Severe hepatic impairment. Pregnancy. Labor & delivery. Nursing mothers.

Stiolto Respimat Pharmacokinetics

See Literature

Stiolto Respimat Interactions


Avoid with other anticholinergics. Caution with concomitant other adrenergic drugs. Concomitant xanthine derivatives, steroids, diuretics may potentiate hypokalemia. Extreme caution with MAOIs, tricyclics, or drugs known to prolong QTc interval. Antagonized by β-blockers; if needed, consider cardioselective agents. Potentiated by strong CYP450 and P-gp inhibitors (eg, ketoconazole).

Stiolto Respimat Adverse Reactions

Adverse Reactions

Nasopharyngitis, cough, back pain; paradoxical bronchospasm, urinary retention, hypokalemia, hypersensitivity reactions.

Stiolto Respimat Clinical Trials

See Literature

Stiolto Respimat Note

Not Applicable

Stiolto Respimat Patient Counseling

See Literature