Solodyn Generic Name & Formulations
Minocycline (as HCl) 55mg, 65mg, 80mg, 105mg, 115mg; ext-rel tabs.
Inflammatory lesions of non-nodular moderate to severe acne.
Solodyn Dosage and Administration
Swallow whole. Give approximately 1mg/kg once daily for 12wks. Weight-based dosing (45–49kg): 45mg; (50–59kg): 55mg; (60–71kg): 65mg; (72–84kg): 80mg; (85–96kg): 90mg; (97–110kg): 105mg; (111–125kg): 115mg; (126–136kg): 135mg. Renal impairment: reduce dose or extend dosing intervals.
<12yrs: not established.
Solodyn Boxed Warnings
Not bioequivalent with other minocycline products. Monitor blood, renal, and hepatic function. Discontinue if superinfection, DRESS syndrome, or autoimmune syndromes develop. Monitor for visual disturbances. Renal or hepatic impairment. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. May interfere with fluorescence test.
Solodyn Adverse Reactions
Headache, fatigue, dizziness, pruritus; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hyperpigmentation, hepatotoxicity, skin/hypersensitivity reactions (may be severe).
Solodyn Clinical Trials
Solodyn Patient Counseling