• Acne

Solodyn Generic Name & Formulations

General Description

Minocycline (as HCl) 55mg, 65mg, 80mg, 105mg, 115mg; ext-rel tabs.

Pharmacological Class

Tetracycline antibiotic.

How Supplied

Ext-rel tabs—30

Solodyn Indications


Inflammatory lesions of non-nodular moderate to severe acne.

Solodyn Dosage and Administration


Swallow whole. Give approximately 1mg/kg once daily for 12wks. Weight-based dosing (45–49kg): 45mg; (50–59kg): 55mg; (60–71kg): 65mg; (72–84kg): 80mg; (85–96kg): 90mg; (97–110kg): 105mg; (111–125kg): 115mg; (126–136kg): 135mg. Renal impairment: reduce dose or extend dosing intervals.


<12yrs: not established.

Solodyn Contraindications

Not Applicable

Solodyn Boxed Warnings

Not Applicable

Solodyn Warnings/Precautions


Not bioequivalent with other minocycline products. Monitor blood, renal, and hepatic function. Discontinue if superinfection, DRESS syndrome, or autoimmune syndromes develop. Monitor for visual disturbances. Renal or hepatic impairment. Avoid sun or UV light. Pregnancy (Cat.D), nursing mothers: not recommended.

Solodyn Pharmacokinetics

See Literature

Solodyn Interactions


Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. May interfere with fluorescence test.

Solodyn Adverse Reactions

Adverse Reactions

Headache, fatigue, dizziness, pruritus; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hyperpigmentation, hepatotoxicity, skin/hypersensitivity reactions (may be severe).

Solodyn Clinical Trials

See Literature

Solodyn Note

Not Applicable

Solodyn Patient Counseling

See Literature