• Bone disorders

Skelid Generic Name & Formulations

General Description

Tiludronate disodium 240mg (equivalent to tiludronate acid 200mg); tabs.

Pharmacological Class


How Supplied

Tabs (200mg)—56


Skelid Indications


Treatment of Paget's disease of bone (osteitis deformans) in patients (1) who have a level of serum alkaline phosphatase at least twice the upper limit of normal, or (2) who are symptomatic, or (3) who are at risk for future complications of their disease.

Skelid Dosage and Administration


Take with 6–8oz of plain water on an empty stomach. 400mg once daily for 3 months. Do not lie down for at least 30 minutes.


Not recommended.

Skelid Contraindications


Inability to stand or sit upright for at least 30 minutes.

Skelid Boxed Warnings

Not Applicable

Skelid Warnings/Precautions


Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Severe renal impairment (CrCl <30mL/min): not recommended. Ensure adequate Vit. D and calcium intake. Pregnancy (Cat.C). Nursing mothers.

Skelid Pharmacokinetics

See Literature

Skelid Interactions


Calcium, aluminum, magnesium, other divalent cations reduce absorption (separate dosing by at least 2hrs). Caution with aspirin, NSAIDs, other GI irritants. Potentiated by indomethacin, separate dosing by 2hrs.

Skelid Adverse Reactions

Adverse Reactions

GI upset; musculoskeletal pain (may be severe), esophagitis; esophageal ulcer, stricture, or erosion, jaw osteonecrosis; rarely: gastric or duodenal ulcer.

Skelid Clinical Trials

See Literature

Skelid Note

Not Applicable

Skelid Patient Counseling

See Literature