Sivextro Injection

  • Bacterial infections

Sivextro Injection Generic Name & Formulations

General Description

Tedizolid phosphate 200mg; lyophilized pwd for IV infusion after reconstitution; preservative-free.

Pharmacological Class


See Also

How Supplied

Tabs—6 (blister pack), 30; Single-dose vials—10

Generic Availability


Sivextro Injection Indications


Susceptible acute bacterial skin and skin structure infections (ABSSSI).

Sivextro Injection Dosage and Administration

Adults and Children

<12yrs: not established. Give by IV over 1 hour. ≥12yrs: 200mg once daily for 6 days. Switching from IV to oral: no dose adjustment necessary.

Sivextro Injection Contraindications

Not Applicable

Sivextro Injection Boxed Warnings

Not Applicable

Sivextro Injection Warnings/Precautions


Not adequately evaluated in patients with neutropenia (ANC <1000 cells/mm3); consider alternate therapies. Risk of C. difficile-associated diarrhea; discontinue if suspected or confirmed. Pregnancy. Nursing mothers.

Sivextro Injection Pharmacokinetics

See Literature

Sivextro Injection Interactions


Tabs: May potentiate oral BCRP substrates; consider interrupting co-administered substrates esp. those with narrow therapeutic index (eg, methotrexate, topotecan); monitor if coadministration (including rosuvastatin) is necessary.

Sivextro Injection Adverse Reactions

Adverse Reactions

Nausea, headache, diarrhea, infusion- or inj site reactions, vomiting, dizziness. In children: phlebitis, increased hepatic transaminases.

Sivextro Injection Clinical Trials

See Literature

Sivextro Injection Note

Not Applicable

Sivextro Injection Patient Counseling

See Literature