Sivextro Injection Generic Name & Formulations
Tedizolid phosphate 200mg; lyophilized pwd for IV infusion after reconstitution; preservative-free.
Tabs—6 (blister pack), 30; Single-dose vials—10
Sivextro Injection Indications
Susceptible acute bacterial skin and skin structure infections (ABSSSI).
Sivextro Injection Dosage and Administration
Adults and Children
<12yrs: not established. Give by IV over 1 hour. ≥12yrs: 200mg once daily for 6 days. Switching from IV to oral: no dose adjustment necessary.
Sivextro Injection Contraindications
Sivextro Injection Boxed Warnings
Sivextro Injection Warnings/Precautions
Not adequately evaluated in patients with neutropenia (ANC <1000 cells/mm3); consider alternate therapies. Risk of C. difficile-associated diarrhea; discontinue if suspected or confirmed. Pregnancy. Nursing mothers.
Sivextro Injection Pharmacokinetics
Sivextro Injection Interactions
Tabs: May potentiate oral BCRP substrates; consider interrupting co-administered substrates esp. those with narrow therapeutic index (eg, methotrexate, topotecan); monitor if coadministration (including rosuvastatin) is necessary.
Sivextro Injection Adverse Reactions
Nausea, headache, diarrhea, infusion- or inj site reactions, vomiting, dizziness. In children: phlebitis, increased hepatic transaminases.
Sivextro Injection Clinical Trials
Sivextro Injection Note
Sivextro Injection Patient Counseling