• Parkinsonism

Sinemet Generic Name & Formulations

General Description

Carbidopa, levodopa; 10mg/100mg, 25mg/100mg, 25mg/250mg; tabs.

Pharmacological Class

Dopa-decarboxylase inhibitor + dopamine precursor.

How Supplied

CR—contact supplier; Tabs—100


Sinemet Indications



Sinemet Dosage and Administration


≥18yrs: Initially one Sinemet 25-100 tab 3 times daily or one Sinemet 10-100 tab 3–4 times daily; increase every 1–2 days up to 2 tabs (of either 25-100 or 10-100 tabs) 4 times daily. If more levodopa is needed, initially one Sinemet 25-250 tab 3–4 times daily; max 8 tabs daily.


<18yrs: not recommended.

Sinemet Contraindications


During or within 14 days of nonselective MAOIs (eg, phenelzine). Narrow-angle glaucoma. Undiagnosed skin lesions. History of melanoma.

Sinemet Boxed Warnings

Not Applicable

Sinemet Warnings/Precautions


Severe cardiovascular or pulmonary disease. Asthma. Renal, hepatic, or endocrine disorders. History of peptic ulcer or MI with residual arrhythmias. Suicidal tendencies. Psychosis. Orthostatic hypotension. Chronic wide-angle glaucoma. Discontinue levodopa at least 12 hrs before starting Sinemet or Sinemet CR. Sinemet CR not bioequivalent to Sinemet; see literature when switching forms. Monitor renal and liver function, intraocular pressure, blood counts. May stain body fluids. Pregnancy (Cat.C). Nursing mothers.

Sinemet Pharmacokinetics

See Literature

Sinemet Interactions


See Contraindications. Orthostatic hypotension with selegiline, antihypertensives. Antagonized by phenothiazines, butyrophenones, risperidone, phenytoin, papaverine. Hypertension, dyskinesia with tricyclic antidepressants. May be antagonized by iron, high protein diets. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.

Sinemet Adverse Reactions

Adverse Reactions

Dyskinesia, GI upset, hallucinations, confusion, psychological disturbances, depression, dizziness, headache, dream abnormalities, dystonia, cardiac arrhythmias, hypotension, dyspnea, on-off phenomenon, back pain, blepharospasm (may indicate excess dosage), hypertension, anticholinergic effects, anorexia, insomnia, leukopenia, renal and liver function disorders, seizures, neuroleptic malignant syndrome.

Sinemet Clinical Trials

See Literature

Sinemet Note

Not Applicable

Sinemet Patient Counseling

See Literature