• Psoriasis

Siliq Generic Name & Formulations

General Description

Brodalumab 210mg/1.5mL; soln for SC inj; preservative-free.

Pharmacological Class

Interleukin-17A antagonist.

How Supplied

Single-dose prefilled syringes—2

Generic Availability


Siliq Indications


Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy and unresponsive to other systemic therapies.

Siliq Dosage and Administration


Give by SC inj into thigh, abdomen (except for area around navel), outer area of upper arm; rotate inj sites. 210mg at Weeks 0, 1, and 2 followed by 210mg every 2 weeks. If adequate response not achieved after 12–16 weeks, consider discontinuing.


Not established.

Siliq Contraindications


Crohn’s disease.

Siliq Boxed Warnings

Boxed Warning

Suicidal ideation and behavior.

Siliq Warnings/Precautions


Risk of suicidal ideation and behavior. History of depression or suicidality. May increase risk of infections. Chronic or history of recurrent infection: consider the risks/benefits. If a serious infection develops or is not responding to standard therapy, monitor closely and discontinue until resolves. Evaluate for TB infection prior to initiating; monitor for active TB during and after therapy. Patients with active TB infection: do not initiate. History of latent or active TB; consider anti-TB therapy prior to initiation. Discontinue if Crohn’s disease develops. Pregnancy. Nursing mothers.



Siliq Pharmacokinetics

See Literature

Siliq Interactions


Avoid concomitant live vaccines. Concomitant CYP450 substrates with a narrow therapeutic index (eg, warfarin, cyclosporine); monitor and consider adjusting dose.

Siliq Adverse Reactions

Adverse Reactions

Arthralgia, headache, fatigue, diarrhea, oropharyngeal pain, nausea, myalgia, inj site reactions, influenza, neutropenia, tinea infections.

Siliq Clinical Trials

See Literature

Siliq Note


Available only through a restricted program under a REMS called the SILIQ REMS Program. For more information, visit or call (855) 511-6135.

Siliq Patient Counseling

See Literature