• Sleep-wake disorders

Silenor Generic Name & Formulations

General Description

Doxepin (as HCl) 3mg, 6mg; tabs.

Pharmacological Class

H1 receptor antagonist.

How Supplied

Tabs—30, 100, 500

Generic Availability


Silenor Indications


Treatment of insomnia characterized by difficulty with sleep maintenance.

Silenor Dosage and Administration


Individualize. Take within 30mins of bedtime. Do not take within 3 hours of a meal. Initially 6mg once daily. Max: 6mg/day. Elderly, hepatic impairment, tendency to urinary retention: initially 3mg once daily.


Not recommended.

Silenor Contraindications


During or within 14 days of MAOIs. Untreated narrow angle glaucoma. Severe urinary retention.

Silenor Boxed Warnings

Not Applicable

Silenor Warnings/Precautions


Evaluate for co-morbid diagnoses (eg, physical or psychiatric disorders) prior to treatment. Reevaluate if insomnia persists after 7–10 days of use. Monitor for new onset behavioral changes, worsening of depression, or suicidal thinking. Hepatic impairment. Respiratory dysfunction. Severe sleep apnea: not recommended. Poor metabolizers (those with reduced CYP2D6/2C19 activity). Reevaluate periodically. Elderly. Neonates (during 3rd trimester). Pregnancy. Nursing mothers: not recommended.

Silenor Pharmacokinetics

See Literature

Silenor Interactions


Additive effects with concomitant CNS depressants, antihistamines, or alcohol (avoid); reduce dose. Potentiated by cimetidine. Possible hypoglycemia with tolazamide.

Silenor Adverse Reactions

Adverse Reactions

Somnolence, sedation, nausea, upper respiratory tract infection, dizziness, photosensitivity, skin rash; abnormal thinking, behavioral changes, complex behaviors, sleep-driving (discontinue if occurs), amnesia, anxiety, other neuro-psychiatric symptoms.

Silenor Clinical Trials

See Literature

Silenor Note

Not Applicable

Silenor Patient Counseling

See Literature