• Acne

Seysara Generic Name & Formulations

General Description

Sarecycline 60mg, 100mg, 150mg; tabs.

Pharmacological Class

Tetracycline antibiotic.

How Supplied



Generic Availability


Seysara Indications


Non-nodular moderate-to-severe acne vulgaris.

Limitations of Use

Efficacy beyond 12 weeks and safety beyond 12 months: not established. Not evaluated in treating infections.

Seysara Dosage and Administration

Adults and Children

<9yrs: not recommended. Take with fluids. ≥9yrs (33–54kg): 60mg once daily; (55–84kg): 100mg once daily; (85–136kg): 150mg once daily. Re-evaluate if no improvement after 12 weeks.

Seysara Contraindications

Not Applicable

Seysara Boxed Warnings

Not Applicable

Seysara Warnings/Precautions


Discontinue if superinfection develops. History of intracranial hypertension. Monitor for visual disturbances. Overweight women. Evaluate if diarrhea occurs; discontinue if C. difficile-associated diarrhea is suspected or confirmed. Avoid sun or UV light. Pregnancy (during 2nd & 3rd trimester): may cause permanent discoloration of the teeth or reversible inhibition of bone growth. Nursing mothers: not recommended.

Seysara Pharmacokinetics

See Literature

Seysara Interactions


Avoid concomitant penicillins, oral retinoids. May need to reduce concomitant anticoagulant dose. Separate dosing from antacids containing aluminum, calcium, magnesium, bismuth subsalicylate, and iron-containing products. Concomitant P-gp substrates (eg, digoxin); monitor for toxicity and reduce dose as needed.

Seysara Adverse Reactions

Adverse Reactions

Nausea; tooth discoloration, enamel hypoplasia, inhibition of bone growth (up to 8yrs of age), C.difficile-associated diarrhea, intracranial hypertension, photosensitivity, CNS effects, male infertility.

Seysara Clinical Trials

See Literature

Seysara Note

Not Applicable

Seysara Patient Counseling

See Literature