• Pituitary disorders

Serostim Generic Name & Formulations

General Description

Somatropin (rDNA origin) 4mg, 5mg, 6mg; per vial; for SC inj after reconstitution.

Pharmacological Class

Growth hormone (GH).

How Supplied

Single-dose vials (5mg, 6mg)—7 (w. diluent); Multi-dose vials (4mg)—7 (w. diluent)


Serostim Indications


HIV patients with wasting or cachexia to increase lean body mass and weight, and improve physical endurance.

Serostim Dosage and Administration


Give by SC inj once daily at bedtime. Rotate inj sites. <35kg: 0.1mg/kg. 35–45kg: 4mg. 45–55kg: 5mg. >55kg: 6mg. Risk factors for adverse effects (eg, glucose intolerance): initially 0.1mg/kg every other day.


Not established; see full labeling.

Serostim Contraindications


Acute critical illness due to surgical complications or multiple accidental trauma or those with acute respiratory failure. Active malignancy. Active proliferative or severe non-proliferative diabetic retinopathy.

Serostim Boxed Warnings

Not Applicable

Serostim Warnings/Precautions


Increased mortality in those with acute critical illness (see Contraindications). Use only under guidance of a physician trained in HIV management. HIV patients should be maintained on antiretroviral therapy. Glucose intolerance. Diabetes. Perform baseline and periodic funduscopic evaluation for intracranial hypertension; discontinue if papilledema occurs; may restart at lower dose after resolution. Monitor for development, progression, or recurrence of neoplasms. Discontinue if carpal tunnel syndrome persists after dosage reduction. Turner syndrome. Elderly. Pregnancy (Cat.B). Nursing mothers.

Serostim Pharmacokinetics

See Literature

Serostim Interactions


May be antagonized by glucocorticoids. May affect CYP450 substrates (eg, corticosteroids, sex steroids, anticonvulsants, cyclosporine); monitor. Concomitant oral estrogens; may require larger somatropin doses. Concomitant insulin and/or hypoglycemics may require dose adjustment.

Serostim Adverse Reactions

Adverse Reactions

Musculoskeletal discomfort, increased tissue turgor, edema, nausea, fatigue, gynecomastia, paresthesia, hypoesthesia, hyperglycemia, hypertriglyceridemia, carpal tunnel syndrome; intracranial hypertension, serious hypersensitivity reactions; rare: pancreatitis.

Serostim Clinical Trials

See Literature

Serostim Note

Not Applicable

Serostim Patient Counseling

See Literature