• Tuberculosis

Seromycin Generic Name & Formulations

General Description

Cycloserine 250mg; caps.

Pharmacological Class


How Supplied



Seromycin Indications


In conjunction with other chemotherapy, for the treatment of active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible and when treatment with primary drugs (streptomycin, isoniazid, rifampin, ethambutol) has proved inadequate.

Seromycin Dosage and Administration


Initially 250mg twice daily at 12-hour intervals for the first 2 weeks. Usual dose: 500mg–1g daily in divided doses monitored by blood levels. Max 1g/day.


Not recommended.

Seromycin Contraindications


Epilepsy. Depression. Severe anxiety. Psychosis. Severe renal insufficiency. Excessive concurrent use of alcohol.

Seromycin Boxed Warnings

Not Applicable

Seromycin Warnings/Precautions


Discontinue or reduce dose if allergic dermatitis or CNS toxicity develops. Ratio of toxic dose to effective dose is small. Monitor blood levels, hematologic, renal, and liver function. Obtain weekly blood levels in patients with reduced renal function, patients receiving >500mg daily dosage, or those showing signs/symptoms suggestive of toxicity. Pregnancy (Cat.C). Nursing mothers: not recommended.

Seromycin Pharmacokinetics

See Literature

Seromycin Interactions


Neurotoxic effects with concomitant ethionamide. Increased risk of epileptic episodes with alcohol. Increased CNS effects with concomitant isoniazid; monitor closely.

Seromycin Adverse Reactions

Adverse Reactions

CNS effects (eg, convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, psychoses, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, seizures, coma), CHF, allergy, rash, elevated serum transaminase (esp. with preexisting liver disease), anemia (monitor).

Seromycin Clinical Trials

See Literature

Seromycin Note

Not Applicable

Seromycin Patient Counseling

See Literature