Selegiline Generic Name & Formulations
Selegiline HCl 5mg; caps.
Adjunct to levodopa/carbidopa in Parkinsonism.
Selegiline Dosage and Administration
5mg at breakfast and at lunch; max 10mg/day. After 2–3 days, levodopa/carbidopa dosage may be reduced by 10–30%; further reductions may be possible later.
Concomitant meperidine, possibly other opioids.
Selegiline Boxed Warnings
Selectivity for MAO type B diminishes at doses over 10mg/day. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Contraindications. Avoid concomitant tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs). Allow at least 5 weeks (or more if used chronically or at high doses) between fluoxetine discontinuance and 2 weeks between paroxetine or sertraline discontinuance before starting selegiline; allow 2 weeks between selegiline discontinuance before starting tricyclic antidepressants or SSRIs. Caution with tyramine-containing foods and with sympathomimetics.
Selegiline Adverse Reactions
Nausea, dizziness, lightheadedness, syncope, abdominal pain, confusion, vivid dreams, hallucinations, dry mouth, headache.
Selegiline Clinical Trials
Formerly known under the brand name Eldepryl.
Selegiline Patient Counseling