• Psychosis

Secuado Generic Name & Formulations

General Description

Asenapine 3.8mg/24hrs, 5.7mg/24hrs, 7.6mg/24hrs; transdermal system.

Pharmacological Class

Atypical antipsychotic.

How Supplied



Generic Availability


Secuado Indications



Secuado Dosage and Administration


Apply to clean, dry, hairless intact skin of the upper arm, upper back, abdomen, or hip. Rotate application site. Initially apply one 3.8mg/24hrs patch once daily; may increase to 5.7mg/24hrs or 7.6mg/24hrs, as needed, after 1 week.


Not established.

Secuado Contraindications


Severe hepatic impairment.

Secuado Boxed Warnings

Boxed Warning

Increased mortality in elderly patients with dementia-related psychosis.

Secuado Warnings/Precautions


Elderly (not for dementia-related psychosis; may increase risk of death). Avoid in congenital long QT syndrome, cardiac arrhythmias. Discontinue if neuroleptic malignant syndrome occurs; consider discontinuing if tardive dyskinesia occurs. Cardio- or cerebrovascular disease. Volume depletion. Pre-existing low WBC/ANC or history of leukopenia/neutropenia; monitor CBCs during 1st few months of treatment; consider discontinuing if significant WBC declines. Monitor for hyperglycemia/diabetes, dyslipidemia, and weight gain prior to or soon after initiation. Perform fall risk assessments when initiating and recurrently on long-term therapy. History of seizures. Strenuous exercise. Exposure to extreme heat. Dehydration. Aspiration risk. Avoid exposing transdermal system to external heat sources. Write ℞ for smallest practical amount. Neonates: may cause extrapyramidal and/or withdrawal symptoms (due to exposure during 3rd-trimester pregnancy). Pregnancy. Nursing mothers.

Secuado Pharmacokinetics

See Literature

Secuado Interactions


Avoid drugs that can prolong QT interval (eg, Class 1A or Class III antiarrhythmics, ziprasidone, chlorpromazine, thioridazine, gatifloxacin, moxifloxacin, alcohol). Potentiates antihypertensives, paroxetine; adjust dose of these drugs. Potentiated by strong CYP1A2 inhibitors (eg, fluvoxamine, ciprofloxacin, enoxacin); reduce dose of Secuado. Caution with other CNS drugs, drugs that are CYP2D6 substrates /inhibitors, drugs that cause orthostatic hypotension, and drugs with anticholinergic activity.

Secuado Adverse Reactions

Adverse Reactions

Application site reactions, extrapyramidal disorder, weight gain, headache, somnolence; orthostatic hypotension, syncope, QT prolongation, leukopenia, dysphagia, hypersensitivity reactions, hyperprolactinemia.

Secuado Clinical Trials

See Literature

Secuado Note

Not Applicable

Secuado Patient Counseling

See Literature