Rythmol Sr Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Tabs—Contact supplier; SR caps—60
Manufacturer
Generic Availability
Rythmol Sr Indications
Indications
Rythmol Sr Dosage and Administration
Adult
Children
Renal Impairment
Approximately 50% of propafenone metabolites are excreted in the urine. Monitor for signs of overdosage in patients with impaired renal function.
Hepatic Impairment
Severe liver dysfunction increases the bioavailability of propafenone to approximately 70%. The clearance of propafenone is reduced and the elimination half-life increased. Carefully monitor patients with impaired hepatic function for excessive effects.
Other Modifications
Exacerbation of myasthenia gravis has been reported during propafenone therapy.
Propafenone may transiently impair spermatogenesis in males.
Rythmol Sr Contraindications
Contraindications
Rythmol Sr Boxed Warnings
Boxed Warning
Rythmol Sr Warnings/Precautions
Warnings/Precautions
Rythmol Sr Pharmacokinetics
Absorption
Maximal plasma levels of propafenone are reached between 3 to 8 hours.
Distribution
Propafenone is greater than 95% protein bound.
Elimination
Extensive metabolizers: Elimination half-life from 2 to 10 hours.
Slow metabolizers: Elimination half-life from 10 to 32 hours.
Rythmol Sr Interactions
Interactions
Rythmol Sr Adverse Reactions
Adverse Reactions
Rythmol Sr Clinical Trials
Rythmol Sr Note
Not Applicable