Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Ryanodex Generic Name & Formulations
Legal Class
Rx
General Description
Dantrolene sodium 250mg; per vial; lyophilized pwd for IV inj after reconstitution.
Pharmacological Class
Muscle relaxant (skeletal).
How Supplied
Single-use vial (20mL)—1 (w. diluent)
Manufacturer
Ryanodex Indications
Indications
Treatment of malignant hyperthermia (MH) in conjunction with appropriate supportive measures. Prevention of malignant hyperthermia in high-risk patients.
Ryanodex Dosage and Administration
Adults and Children
Treatment: Give by IV push at a minimum of 1mg/kg; if psychologic and metabolic abnormalities continues or reappear, repeat dosing; max cumulative dose: 10mg/kg. Prevention: Start approx. 75 mins prior to surgery. 2.5mg/kg by IV over ≥1 min; may give additional doses if surgery prolonged.
Ryanodex Contraindications
Not Applicable
Ryanodex Boxed Warnings
Not Applicable
Ryanodex Warnings/Precautions
Warnings/Precautions
Institute supportive measures (eg, discontinue MH-triggering agents, manage metabolic acidosis, cooling if necessary, diuretic administration). Monitor for skeletal muscle weakness, adequate ventilation, difficulty swallowing and choking. Avoid extravasation. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Ryanodex Pharmacokinetics
See Literature
Ryanodex Interactions
Interactions
Avoid MH-triggering agents. Increased risk of somnolence or dizziness with concomitant sedative agents. Concomitant calcium channel blockers: not recommended. Concomitant other muscle relaxants may potentiate neuromuscular block. Increased CNS effects with concomitant antipsychotics, anxiolytics.
Ryanodex Adverse Reactions
Adverse Reactions
Loss of grip strength, weakness in the legs, drowsiness, flushing, somnolence, dizziness, nausea, thrombophlebitis, tissue necrosis secondary to extravasation, urticaria, inj site reactions (eg, pain, erythema, swelling); dyspnea, dysphasia.
Ryanodex Clinical Trials
See Literature
Ryanodex Note
Not Applicable
Ryanodex Patient Counseling
See Literature
