• Inborn errors of metabolism

Ryanodex Generic Name & Formulations

General Description

Dantrolene sodium 250mg; per vial; lyophilized pwd for IV inj after reconstitution.

Pharmacological Class

Muscle relaxant (skeletal).

How Supplied

Single-use vial (20mL)—1 (w. diluent)


Ryanodex Indications


Treatment of malignant hyperthermia (MH) in conjunction with appropriate supportive measures. Prevention of malignant hyperthermia in high-risk patients.

Ryanodex Dosage and Administration

Adults and Children

Treatment: Give by IV push at a minimum of 1mg/kg; if psychologic and metabolic abnormalities continues or reappear, repeat dosing; max cumulative dose: 10mg/kg. Prevention: Start approx. 75 mins prior to surgery. 2.5mg/kg by IV over ≥1 min; may give additional doses if surgery prolonged.

Ryanodex Contraindications

Not Applicable

Ryanodex Boxed Warnings

Not Applicable

Ryanodex Warnings/Precautions


Institute supportive measures (eg, discontinue MH-triggering agents, manage metabolic acidosis, cooling if necessary, diuretic administration). Monitor for skeletal muscle weakness, adequate ventilation, difficulty swallowing and choking. Avoid extravasation. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Ryanodex Pharmacokinetics

See Literature

Ryanodex Interactions


Avoid MH-triggering agents. Increased risk of somnolence or dizziness with concomitant sedative agents. Concomitant calcium channel blockers: not recommended. Concomitant other muscle relaxants may potentiate neuromuscular block. Increased CNS effects with concomitant antipsychotics, anxiolytics.

Ryanodex Adverse Reactions

Adverse Reactions

Loss of grip strength, weakness in the legs, drowsiness, flushing, somnolence, dizziness, nausea, thrombophlebitis, tissue necrosis secondary to extravasation, urticaria, inj site reactions (eg, pain, erythema, swelling); dyspnea, dysphasia.

Ryanodex Clinical Trials

See Literature

Ryanodex Note

Not Applicable

Ryanodex Patient Counseling

See Literature