Rukobia

— THERAPEUTIC CATEGORIES —
  • Viral infections

Rukobia Generic Name & Formulations

General Description

Fostemsavir 600mg; ext-rel tabs.

Pharmacological Class

HIV-1 gp120-directed attachment inhibitor.

How Supplied

Ext-rel tabs—60

Manufacturer

Generic Availability

NO

Rukobia Indications

Indications

In combination with other antiretroviral(s), for the treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 infection failing their current antiretroviral regimen.

Rukobia Dosage and Administration

Adult

Swallow whole. 600mg twice daily.

Children

Not established.

Rukobia Contraindications

Contraindications

Concomitant strong CYP3A4 inducers (eg, enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, St. John's wort).

Rukobia Boxed Warnings

Not Applicable

Rukobia Warnings/Precautions

Warnings/Precautions

History of QTc interval prolongation. Preexisting cardiac disease. Immune reconstitution syndrome. Monitor LFTs in those with hepatitis B and/or C coinfection. Elderly. Pregnancy. Nursing mothers: not recommended.

Rukobia Pharmacokinetics

See Literature

Rukobia Interactions

Interactions

See Contraindications. May be antagonized by strong CYP3A4 inducers. May potentiate HCV direct-acting antivirals (eg, grazoprevir, voxilaprevir), statins drugs (eg, rosuvastatin, atorvastatin, fluvastatin, pitavastatin, simvastatin), ethinyl estradiol. Caution when concomitant drugs with a known risk for Torsade de Pointes.

Rukobia Adverse Reactions

Adverse Reactions

Nausea, diarrhea, headache, abdominal pain, dyspepsia, fatigue, rash, sleep disturbance; elevated transaminases.

Rukobia Clinical Trials

See Literature

Rukobia Note

Not Applicable

Rukobia Patient Counseling

See Literature

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