Ruconest Generic Name & Formulations
C1 esterase inhibitor (recombinant) 2100 IU; per vial; lyophilized pwd for IV inj after reconstitution; preservative-free.
Treatment of acute attacks in adult and adolescent patients with hereditary angioedema (HAE).
Limitations of Use
Efficacy not established in HAE patients with laryngeal attacks.
Ruconest Dosage and Administration
Give by slow IV inj over 5 mins. <84kg: 50 IU/kg. ≥84kg: 4200 IU. Max 4200 IU/dose. May give second dose if attack symptoms persist; max 2 doses/24hrs.
Allergy to rabbits or rabbit-derived products.
Ruconest Boxed Warnings
Discontinue if hypersensitivity reactions occur. Monitor patients with known risk factors for thrombotic events (eg, indwelling venous catheter, history of thrombosis, atherosclerosis, morbid obesity, immobility). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
Risk of thrombotic events with concomitant oral contraceptives or certain androgens.
Ruconest Adverse Reactions
Headache, nausea, diarrhea; thrombotic events, hypersensitivity reactions (may be severe).
Ruconest Clinical Trials
Ruconest Patient Counseling