Colorectal disorders:

Indications for ROWASA:

Mild to moderate distal ulcerative colitis, proctosigmoiditis, proctitis.

Adult Dosage:

4g (60mL) daily at bedtime for 3–6 weeks. Retain enema for 8 hours.

Children Dosage:

Not established.

ROWASA Warnings/Precautions:

Sulfite sensitivity. Sulfasalazine allergy. Discontinue if acute intolerance syndrome is suspected. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Nephrolithiasis. Ensure adequate hydration. Renal or hepatic impairment. Monitor renal function prior to and periodically during therapy. Elderly (monitor CBCs, platelets). Pregnancy. Nursing mothers: monitor infants.

ROWASA Classification:

Salicylate.

ROWASA Interactions:

Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other drugs known to cause myelotoxicity. May cause elevated test results when measuring urinary normetanephrine; consider other alternative assay.

Adverse Reactions:

Abdominal pain/cramps/discomfort, headache, flatulence, nausea, diarrhea, flu, malaise, fever, sore throat, dizziness, bloating, joint, back, or rectal pain, hemorrhoids, itching, constipation, hair loss, pancolitis, pericarditis, rash; renal impairment, acute intolerance syndrome, hypersensitivity reactions (including myocarditis, pericarditis, pneumonitis, hematologic abnormalities, others).

Generic Drug Availability:

YES

How Supplied:

Enema—7, 14, 28

Pricing for ROWASA

7 bottles of 4g/60ml carton (Qty: 4)
Appx. price $207
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