Ritalin La Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Ritalin La Indications
Indications
Ritalin La Dosage and Administration
Adults and Children
Ritalin La Contraindications
Contraindications
Ritalin La Boxed Warnings
Boxed Warning
Ritalin La Warnings/Precautions
Warnings/Precautions
Ritalin La Pharmacokinetics
Absorption
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The absolute oral bioavailability of methylphenidate in children was 22 ± 8% for d-methylphenidate and 5 ± 3% for l-methylphenidate.
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The relative bioavailability of Ritalin LA given once daily is comparable to the same total dose of Ritalin tablets given in 2 doses 4 hours apart in both children and adults.
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The initial rate of absorption for Ritalin LA is similar to that of Ritalin tablets as shown by the similar rate parameters between the 2 formulations, i.e., initial lag time (Tlag), first peak concentration (Cmax1), and time to the first peak (Tmax1), which is reached in 1 to 3 hours.
Distribution
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Binding to plasma proteins is low (10% to 33%).
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The volume of distribution was 2.65 ± 1.11 L/kg for d- methylphenidate and 1.80 ± 0.91 L/kg for l-methylphenidate.
Elimination
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After oral administration, 78% to 97% of the dose is excreted in the urine and 1% to 3% in feces in the form of metabolites within 48 to 96 hours.
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Most of the dose is excreted in the urine as alpha-phenyl-2-piperidine acetic acid (60% to 86%).
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The systemic clearance is 0.40 ± 0.12 L/h/kg for d-methylphenidate and 0.73 ± 0.28 L/h/kg for l-methylphenidate.
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Elimination half-life is about 3.5 hours (range, 1.3 to 7.7 hours) in adults, and 2.5 hours (range, 1.5 to 5.0 hours) in children.
Ritalin La Interactions
Interactions
Ritalin La Adverse Reactions
Adverse Reactions
Ritalin La Clinical Trials
Ritalin La Note
Not Applicable
Ritalin La Patient Counseling
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