• Cough and cold

Rezira Generic Name & Formulations

General Description

Hydrocodone bitartrate 5mg, pseudoephedrine hydrochloride 60mg; per 5mL; oral soln; grape-flavor.

Pharmacological Class

Antitussive + sympathomimetic.

How Supplied


Rezira Indications


Cough and nasal congestion associated with common cold.

Rezira Dosage and Administration


Use accurate measuring device. ≥18yrs: 5mL every 4–6hrs as needed. Max: 4 doses (20mL) per 24hrs.


<18yrs: not established.

Rezira Contraindications


During or within 14 days of MAOIs. Narrow angle glaucoma. Urinary retention. Severe hypertension. Severe coronary artery disease.

Rezira Boxed Warnings

Boxed Warning

Risks from concomitant use with benzodiazepines or other CNS depressants.

Rezira Warnings/Precautions


Risks from concomitant benzodiazepines or other CNS depressants (see Interactions). Discontinue if respiratory depression occurs. Abuse potential (monitor). Avoid in head injury, other intracranial lesions or pre-existing increase in intracranial pressure. Acute abdomen. Cardiovascular disorders. Diabetes. Thyroid disorders. Addison's disease. Prostatic hypertrophy. Urethral stricture. Asthma. Severe hepatic or renal impairment. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Rezira Pharmacokinetics

See Literature

Rezira Interactions


See Contraindications. Increased risk of respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, opioids, antihistamines, antipsychotics, anxiolytics, alcohol); avoid. Hypertensive crisis with MAOIs. May affect or be affected by TCAs. Paralytic ileus may occur with anticholinergics.

Rezira Adverse Reactions

Adverse Reactions

Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes, nervousness or sleeplessness, tremor, arrhythmia; respiratory depression, cardiovascular effects.

Rezira Clinical Trials

See Literature

Rezira Note

Not Applicable

Rezira Patient Counseling

See Literature