Migraine and headache:
Indications for REYVOW:
Acute treatment of migraine with or without aura.
Limitations of Use:
Not for preventive treatment of migraine.
Swallow whole. 50–200mg once as needed; max 1 dose/24hrs. Do not administer unless patient can wait ≥8hrs between dosing and driving/operating machinery. The safety of treating an average of >4 migraine attacks in a 30-day period: not established.
Driving impairment (see Adults). CNS depression. Discontinue if serotonin syndrome is suspected. Medication overuse headache; may need detoxification. Severe hepatic impairment (Child-Pugh C): not recommended. Elderly. Pregnancy. Nursing mothers.
Serotonin (5-HT) 1F receptor agonist.
Avoid concomitant P-gp or BCRP substrates. May potentiate CNS depression with alcohol or other CNS depressants. May increase risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, TCAs, MAOIs, trazodone, dextromethorphan, St. John's Wort). Caution with drugs that lower heart rate (eg, propranolol).
Dizziness, fatigue, paresthesia, sedation.