Revatio Oral Suspension Generic Name & Formulations
Sildenafil 10mg/mL; pwd for oral susp after reconstitution; grape flavor; contains sorbitol.
Phosphodiesterase type 5 inhibitor (cGMP-specific).
Tabs—90; Susp—112mL (w. bottle adapter, oral syringe); Single-use vial (12.5mL)—1
Tabs (YES); Susp, inj (NO)
Revatio Oral Suspension Indications
Pulmonary arterial hypertension (PAH) (WHO Group I) to improve exercise ability and delay clinical worsening.
Limitations of Use
No beneficial effect on exercise capacity in adding sildenafil to bosentan therapy.
Revatio Oral Suspension Dosage and Administration
5mg or 20mg three times daily; separate dosing by 4–6hrs. Max: 20mg three times daily.
Revatio Oral Suspension Contraindications
Concomitant organic nitrates, riociguat.
Revatio Oral Suspension Boxed Warnings
Revatio Oral Suspension Warnings/Precautions
Pulmonary veno-occlusive disease: not recommended. PAH secondary to sickle cell anemia (risk of vaso-occlusive crisis). Underlying conditions that could be affected by vasodilatory effects (eg, concomitant antihypertensive therapy, BP<90/50, fluid depletion, severe left ventricular outflow obstruction, autonomic dysfunction). Risk of non-arteritic anterior ischemic optic neuropathy; monitor for sudden vision loss. Retinitis pigmentosa. Anatomical penile deformation. Predisposition to priapism. Severe hepatic impairment. Active peptic ulcer. Bleeding disorders. Elderly. Pregnancy. Nursing mothers.
Revatio Oral Suspension Pharmacokinetics
Revatio Oral Suspension Interactions
See Contraindications. Hypotension with nitrates. Concomitant potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir): not recommended. May be antagonized by CYP3A4 inducers. Concomitant α-blockers (eg, doxazosin) or amlodipine may cause symptomatic hypotension (monitor BP). Increased epistaxis with Vit. K antagonists. Avoid concomitant Viagra or other PDE5 inhibitors.
Revatio Oral Suspension Adverse Reactions
Epistaxis, headache, dyspepsia, flushing, insomnia, erythema, dyspnea, rhinitis; hypotension, vision or hearing loss, priapism.
Revatio Oral Suspension Clinical Trials
Revatio Oral Suspension Note
Revatio Oral Suspension Patient Counseling