Retrovir Syrup Generic Name & Formulations
Zidovudine 10mg/mL; strawberry flavor.
Nucleoside analogue (reverse transcriptase inhibitor).
Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—1, 5
Retrovir Syrup Indications
HIV-1 infection, in combination with other antiretroviral agents. Prevention of maternal-fetal HIV-1 transmission.
Retrovir Syrup Dosage and Administration
≥18yrs: 300mg twice daily. Renal impairment (CrCl <15mL/min) or on dialysis: 100mg every 6–8hrs. Prevention of maternal-fetal HIV or vertical transmission, severe anemia and/or neutropenia: see full labeling.
<6wks and/or for vertical transmission: see full labeling. 4wks to <18yrs: (4 to <9kg): 24mg/kg/day (12mg/kg twice daily or 8mg/kg 3 times daily); (≥9 to <30kg): 18mg/kg/day (9mg/kg twice daily or 6mg/kg 3 times daily); (≥30kg): 600mg/day (300mg twice daily or 200mg 3 times daily). Alternative dosing based on BSA: 480mg/m2/day (240mg/m2 twice daily or 160mg/m2 3 times daily).
Retrovir Syrup Contraindications
Retrovir Syrup Boxed Warnings
Hematological toxicity. Myopathy. Lactic acidosis and severe hepatomegaly with steatosis.
Retrovir Syrup Warnings/Precautions
Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy/myositis with prolonged use. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for lipoatrophy; use alternatives if suspected. Severe renal impairment: reduce dose (see Adult). Hepatic impairment or cirrhosis: monitor for hematologic toxicity. Latex allergy (IV). Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.
Retrovir Syrup Pharmacokinetics
Retrovir Syrup Interactions
Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin). Increased hematologic toxicity with ganciclovir, interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon alpha with or without ribavirin.
Retrovir Syrup Adverse Reactions
Headache, malaise, nausea, vomiting, anorexia; neutropenia, anemia, myopathy, lactic acidosis, severe hepatomegaly with steatosis, immune reconstitution syndrome, pancreatitis, lipoatrophy. Children: also fever, cough.
Retrovir Syrup Clinical Trials
Retrovir Syrup Note
Retrovir Syrup Patient Counseling