Retrovir Iv

  • Viral infections

Retrovir Iv Generic Name & Formulations

General Description

Zidovudine 10mg/mL; for IV infusion after dilution; preservative-free.

Pharmacological Class

Nucleoside analogue (reverse transcriptase inhibitor).

How Supplied

Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—1, 5


Generic Availability


Retrovir Iv Indications


HIV-1 infection, in combination with other antiretroviral agents. Prevention of maternal-fetal HIV-1 transmission.

Retrovir Iv Dosage and Administration


Give by IV infusion over 1hr; use only until oral therapy can be given. 1mg/kg every 4hrs. Renal impairment (CrCL <15mL/min) or on dialysis: 1mg/kg every 6–8hrs. Prevention of maternal-fetal HIV or vertical transmission, severe anemia and/or neutropenia: see full labeling.


Vertical transmission: see full labeling.

Retrovir Iv Contraindications

Not Applicable

Retrovir Iv Boxed Warnings

Boxed Warning

Hematological toxicity. Myopathy. Lactic acidosis and severe hepatomegaly with steatosis.

Retrovir Iv Warnings/Precautions


Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy/myositis with prolonged use. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for lipoatrophy; use alternatives if suspected. Severe renal impairment: reduce dose (see Adult). Hepatic impairment or cirrhosis: monitor for hematologic toxicity. Latex allergy (IV). Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.

Retrovir Iv Pharmacokinetics

See Literature

Retrovir Iv Interactions


Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin). Increased hematologic toxicity with ganciclovir, interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon alpha with or without ribavirin.

Retrovir Iv Adverse Reactions

Adverse Reactions

Headache, malaise, nausea, vomiting, anorexia; neutropenia, anemia, myopathy, lactic acidosis, severe hepatomegaly with steatosis, immune reconstitution syndrome, pancreatitis, lipoatrophy. Children: also fever, cough.

Retrovir Iv Clinical Trials

See Literature

Retrovir Iv Note

Not Applicable

Retrovir Iv Patient Counseling

See Literature