• Thromboembolic disorders

Retavase Generic Name & Formulations

General Description

Reteplase 10 units; per vial; lyophilized pwd for IV inj after reconstitution; preservative-free.

Pharmacological Class

Tissue plasminogen activator (tPA).

How Supplied

Kit—1 (2 vials w. diluents, supplies); Half-Kit—1 (1 vial w. diluent, supplies)


Mechanism of Action

Reteplase is a recombinant plasminogen activator which catalyzes the cleavage of endogenous plasminogen to generate plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.

Retavase Indications


Treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of death and heart failure. 

Limitations of Use

The risk of stroke may outweigh the benefit produced by thrombolytic
therapy in patients whose STEMI puts them at low risk for death or heart failure. 

Retavase Dosage and Administration


Start as soon as possible after onset of STEMI. 10 units IV over 2mins; repeat with 10 units 30mins after the first dose.


Not established.

Retavase Contraindications


Active internal bleeding. Recent stroke. Intracranial or intraspinal surgery or serious head trauma within 3 months. Intracranial neoplasm, arteriovenous malformation, or aneurysm. Bleeding diathesis. Severe uncontrolled hypertension.

Retavase Boxed Warnings

Not Applicable

Retavase Warnings/Precautions


Avoid noncompressible arterial puncture, internal jugular and subclavian venous punctures, IM inj, nonessential handling of patient to minimize risk of bleeding. Withhold second dose if serious bleeding or anaphylactoid reaction occurs. Discontinue concomitant anticoagulant therapy if severe bleeding occurs. Cholesterol embolization. Pregnancy. Nursing mothers: not studied.

Retavase Pharmacokinetics




Renal. Half-life: 13–16 minutes.

Retavase Interactions


Increased bleeding risk with concomitant anticoagulant therapy. Incompatible with heparin; do not administer through an IV line together. Coagulation tests may be unreliable during therapy.

Retavase Adverse Reactions

Adverse Reactions

Bleeding, hypersensitivity reactions, cholesterol embolism.

Retavase Clinical Trials

See Literature

Retavase Note

Not Applicable

Retavase Patient Counseling

See Literature