Thromboembolic disorders:

Indications for: RETAVASE

Management of acute myocardial infarction (AMI) to improve ventricular function and to reduce the incidence of congestive heart failure and mortality.

Adult Dosage:

Start as soon as possible after onset of AMI symptoms. 10Units as IV bolus over 2 minutes; repeat dose 30 minutes after initiation of 1st bolus.

Children Dosage:

Not recommended.

RETAVASE Contraindications:

Active internal bleeding. History of cerebrovascular accident. Recent intracranial or intraspinal surgery or trauma. Intracranial neoplasm, arteriovenous malformation, or aneurysm. Bleeding diathesis. Severe uncontrolled hypertension.

RETAVASE Warnings/Precautions:

Avoid noncompressible arterial puncture, internal jugular and subclavian venous punctures, IM inj, nonessential handling of patient to minimize risk of bleeding. Discontinue concomitant anticoagulant therapy if severe bleeding occurs. Recent major surgery. Cerebrovascular disease. GI or GU bleeding. Hypertension. Left heart thrombus. Acute pericarditis. Subacute bacterial endocarditis. Hemostatic defects. Severe hepatic or renal dysfunction. Hemorrhagic ophthalmic conditions. Septic thrombophlebitis. Occluded AV cannula. Elderly. Pregnancy (Cat.C). Nursing mothers.

RETAVASE Classification:

Tissue plasminogen activator (tPA).

RETAVASE Interactions:

Bleeding risks increased with heparin, vitamin K antagonists, aspirin, dipyridamole, abciximab. Coagulation tests may be unreliable during therapy.

Adverse Reactions:

Bleeding, hypersensitivity reactions, GI upset, hypotension, fever; cardiogenic shock, arrhythmias, AV block, pulmonary edema, heart failure, cardiac arrest, ischemia, reinfarction, myocardial rupture, mitral regurgitation, pericardial effusion, pericarditis, cardiac tamponade, venous thrombosis, cholesterol embolism, electromechanical dissociation.

How Supplied:

Kit—1 (2 vials w. diluents, supplies)
Half-Kit—1 (1 vial w. diluent)