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Renvela For Oral Suspension Generic Name & Formulations
Legal Class
Rx
General Description
Sevelamer carbonate 0.8g, 2.4g; per packet; pwd for oral susp.
Pharmacological Class
Phosphate binder.
See Also
How Supplied
Tabs—30, 270; Packets—90
Manufacturer
Renvela For Oral Suspension Indications
Indications
Control of serum phosphorus in patients ≥6yrs with chronic kidney disease on dialysis.
Renvela For Oral Suspension Dosage and Administration
Adult
Take with meals. Mix with 30mL (0.8g packet) or 60mL (2.4g packet) of water; drink mixture within 30mins. Patients not taking a phosphate binder: serum phosphorus >5.5 and <7.5mg/dL: 800mg 3 times daily; ≥7.5mg/dL: 1.6g 3 times daily. Titrate by 800mg/meal at 2-week intervals to serum phosphorus target range; average max 7.2g/day. Switching from sevelamer HCl or switching between sevelamer carbonate tabs and pwd: use same dose in grams. Switching from calcium acetate: sevelamer carbonate 800mg approximates calcium acetate 667mg (see full labeling).
Children
<6yrs: not established. ≥6yrs: Take with meals. Mix with 30mL (0.4g or 0.8g packet) or 60mL (2.4g packet) of water; drink mixture within 30mins. Patients not taking a phosphate binder: BSA: ≥0.75–<1.2m2: 800mg 3 times daily; titrate by 400mg/dose at 2-week intervals to achieve target levels; ≥1.2m2: 1.6g 3 times daily; titrate by 800mg/dose at 2-week intervals to achieve target levels.
Renvela For Oral Suspension Contraindications
Contraindications
Bowel obstruction.
Renvela For Oral Suspension Boxed Warnings
Not Applicable
Renvela For Oral Suspension Warnings/Precautions
Warnings/Precautions
Dysphagia. Swallowing disorders (use susp. form). Severe GI motility disorders. Major GI tract surgery. Pregnancy.
Renvela For Oral Suspension Pharmacokinetics
See Literature
Renvela For Oral Suspension Interactions
Interactions
Concomitant with drugs that have a narrow therapeutic index; monitor. Consider separation of administration with cyclosporine, tacrolimus, or levothyroxine. Separate dosing of ciprofloxacin by ≥2hrs before or 6hrs after sevelamer; mycophenolate mofetil by ≥2hrs before sevelamer.
Renvela For Oral Suspension Adverse Reactions
Adverse Reactions
Nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, constipation; rare: bowel obstruction, perforation.
Renvela For Oral Suspension Clinical Trials
See Literature
Renvela For Oral Suspension Note
Not Applicable
Renvela For Oral Suspension Patient Counseling
See Literature
