Relistor Generic Name & Formulations
Methylnaltrexone bromide 150mg; tabs.
Opioid antagonist (peripheral).
Tabs—60, 90; Single-use vial (12mg/0.6mL)—1; Prefilled syringes (8mg/0.4mL)—7; Prefilled syringes (12mg/0.6mL)—1, 7
Opioid-induced constipation (OIC) in adults with chronic non-cancer pain, including chronic pain related to prior cancer or its treatment in patients who do not require frequent opioid dosage escalation.
Relistor Dosage and Administration
Discontinue all maintenance laxatives prior to initiation; may be used if suboptimal methylnaltrexone response after 3 days. Reevaluate if opioid regimen is changed. Take on an empty stomach with water ≥30mins before first meal of day. 450mg once daily in the AM. Moderate or severe renal (CrCl<60mL/min) or hepatic (Child-Pugh B or C) impairment: 150mg once daily.
Known or suspected GI obstruction and at increased risk of recurrent obstruction.
Relistor Boxed Warnings
Discontinue if concurrent opioid pain medication is also discontinued. GI perforation; monitor for severe, persistent, or worsening abdominal pain; discontinue if occurs. Discontinue if severe or persistent diarrhea occurs. Increased risk of opioid withdrawal and/or reduced analgesia in those with blood-brain barrier disruptions; monitor for symptoms. Bowel movement may occur within 30 mins of dosing. Elderly. Pregnancy. Nursing mothers: not recommended.
Potential additive effects and increased risk of opioid withdrawal with concomitant other opioid antagonists; avoid.
Relistor Adverse Reactions
Abdominal pain, flatulence, nausea, dizziness, diarrhea, headache, abdominal distention, vomiting, hyperhidrosis, anxiety, muscle spasms, rhinorrhea, chills, tremor, hot flush; GI perforation, opioid withdrawal.
Relistor Clinical Trials
Relistor Patient Counseling