• Viral infections

Relenza Generic Name & Formulations

General Description

Zanamivir 5mg/blister; dry pwd for oral inhalation; contains lactose.

Pharmacological Class

Neuraminidase inhibitor.

How Supplied

Rotadisk (4 blisters)—5 (w. 1 Diskhaler)


Relenza Indications


Treatment of uncomplicated acute illness due to influenza A and B virus in patients ≥7 years of age who have been symptomatic for no more than two days. Prophylaxis of influenza in patients ≥5 years of age.

Relenza Dosage and Administration

Adults and Children

Use supplied Diskhaler inhalation device. Complete course of treatment. Treatment: <7yrs: not established. ≥7yrs: 2 inh (10mg total) twice daily (at least 2 hrs apart) on 1st day; then 2 inh (10mg total) twice daily at 12-hr intervals for the next 4 days (5 days total). Prophylaxis: <5yrs: not established. ≥5yrs: 2 inh (10mg total) once daily. Household: use for 10 days. Community: use for 28 days.

Relenza Contraindications


Milk protein allergy.

Relenza Boxed Warnings

Not Applicable

Relenza Warnings/Precautions


Underlying airway disease (eg, asthma, COPD): not recommended; if used, patient must have a fast-acting bronchodilator available. Discontinue if bronchospasm or decline in respiratory function occurs or worsens. Do not use for prophylaxis in nursing home setting. Monitor for signs of abnormal behavior (esp. in children). High-risk underlying medical conditions. Pregnancy. Nursing mothers.

Relenza Pharmacokinetics

See Literature

Relenza Interactions


If an inhaled bronchodilator is scheduled for dosing at the same time, use the bronchodilator first. Caution with influenza virus vaccine live, intranasal (eg, FluMist); separate dosing by at least 48hrs before or 2 weeks after FluMist. May maintain normal influenza virus vaccine schedule.

Relenza Adverse Reactions

Adverse Reactions

Sinusitis, dizziness, fever/chills, arthralgia, articular rheumatism; bronchospasm, allergic reactions (eg, oropharyngeal edema), possible neuropsychiatric events (eg, seizures, confusion, abnormal behavior).

Relenza Clinical Trials

See Literature

Relenza Note

Not Applicable

Relenza Patient Counseling

See Literature