Razadyne Er

  • Alzheimer's dementia

Razadyne Er Generic Name & Formulations

General Description

Galantamine (as HBr) 8mg, 16mg, 24mg; ext-rel caps.

Pharmacological Class

Reversible acetylcholinesterase inhibitor (benzazepine deriv).

How Supplied

Tabs, soln—contact supplier; ER caps—30

Razadyne Er Indications


Mild to moderate Alzheimer's dementia.

Razadyne Er Dosage and Administration


Give with AM meal. Initially 8mg/day; if well-tolerated, increase to maintenance dose 16mg/day after minimum of 4 weeks; may attempt further increase to max 24mg/day after minimum of 4 weeks. Re-titrate if interrupted for >3 days. Moderate hepatic or renal impairment (CrCl 9–59mL/min): usual max 16mg/day.


Not established.

Razadyne Er Contraindications

Not Applicable

Razadyne Er Boxed Warnings

Not Applicable

Razadyne Er Warnings/Precautions


Discontinue at the first sign of skin rash, unless not drug-related; consider alternative therapy if serious skin reactions occur. Conduction disorders (eg, bradycardia, AV block). History of ulcer disease. Bladder outflow obstruction. Asthma. COPD. Seizures. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9mL/min): not recommended. Pregnancy. Nursing mothers.

Razadyne Er Pharmacokinetics

See Literature

Razadyne Er Interactions


Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs.

Razadyne Er Adverse Reactions

Adverse Reactions

Nausea, vomiting, diarrhea, dizziness, headache, decreased appetite, anorexia, weight loss, syncope, bradycardia, heart block, seizures; serious skin reactions (eg, Stevens-Johnson syndrome).

Razadyne Er Clinical Trials

See Literature

Razadyne Er Note

Not Applicable

Razadyne Er Patient Counseling

See Literature