Bacterial infections:

Indications for: Raxibacumab

Treatment of inhalational anthrax in combination with appropriate antibacterial drugs. Prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.

Limitations of Use:

Has no direct antibacterial activity. Does not cross the blood-brain barrier. Does not prevent or treat meningitis. Pediatrics: safety and pharmacokinetics were not studied.

Adult Dosage:

See full labeling. Premedicate with diphenhydramine (oral or IV) within 1hr prior to raxibacumab infusion. Give as IV infusion over 135mins. 40mg/kg.

Children Dosage:

See full labeling. Premedicate with diphenhydramine (oral or IV) within 1hr prior to raxibacumab infusion. Give as IV infusion over 135mins. ≤10kg: 80mg/kg. >10–40kg: 60mg/kg. >40kg: 40mg/kg.

Boxed Warning:

Hypersensitivity and anaphylaxis.

Raxibacumab Warnings/Precautions:

Have resuscitative equipment and medication readily available. Monitor infusion during and after administration. Interrupt or discontinue if hypersensitivity reactions or anaphylaxis occur; treat appropriately. Pregnancy. Nursing mothers.

Raxibacumab Classification:

Monoclonal antibody.

Adverse Reactions:

Rash, pain in extremity, pruritus, somnolence.

Generic Drug Availability:

NO

How Supplied:

Single-use vial (34mL)—1