• Viral infections

Rapivab Generic Name & Formulations

General Description

Peramivir 10mg/mL; per vial; soln for IV inj after dilution; preservative-free.

Pharmacological Class

Neuraminidase inhibitor.

How Supplied

Single-use vials (20mL)—3

Generic Availability


Rapivab Indications


Treatment of acute uncomplicated influenza in patients who have been symptomatic for ≤2 days.

Limitations of Use

Efficacy based on predominantly influenza A virus infections; limited number of influenza B virus subjects were enrolled. Consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use. Efficacy not established in patients with serious influenza requiring hospitalization.

Rapivab Dosage and Administration


Start within 2 days of symptom onset. Give as IV infusion over 15–30mins. ≥13yrs: 600mg as a single dose. Renal impairment (CrCl 30–49mL/min): 200mg; (CrCl 10–29mL/min): 100mg; (on hemodialysis): give after dialysis.


<6months: not established. Start within 2 days of symptom onset. Give as IV infusion over 15–30mins. 6months–12yrs: 12mg/kg as a single dose (max 600mg). Renal impairment: 6months–<2yrs (CrCl <50mL/min): no data; 2–12yrs (CrCl 30–49mL/min): 4mg/kg; (CrCl 10–29mL/min): 2mg/kg; (on hemodialysis): give after dialysis.

Rapivab Contraindications

Not Applicable

Rapivab Boxed Warnings

Not Applicable

Rapivab Warnings/Precautions


Discontinue if anaphylaxis or serious skin reaction (eg, erythema multiforme, Stevens-Johnson syndrome) occurs or is suspected. Monitor closely for signs of abnormal behavior. Risk of secondary bacterial infections; treat as appropriate. Pregnancy. Nursing mothers.

Rapivab Pharmacokinetics

See Literature

Rapivab Interactions


Avoid live attenuated influenza vaccine within 2wks prior or 48hrs after treatment.

Rapivab Adverse Reactions

Adverse Reactions

Diarrhea; neuropsychiatric events (eg, hallucinations, delirium, abnormal behavior); rare: serious skin reactions, anaphylaxis.

Rapivab Clinical Trials

See Literature

Rapivab Note

Not Applicable

Rapivab Patient Counseling

See Literature