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Ranexa Generic Name & Formulations
Legal Class
Rx
General Description
Ranolazine 500mg, 1000mg; ext-rel tabs.
Pharmacological Class
Antianginal.
How Supplied
Tabs—60
Manufacturer
Ranexa Indications
Indications
Chronic angina; may be used with beta-blockers, nitrates, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, anti-platelet and lipid-lowering therapies.
Ranexa Dosage and Administration
Adult
Swallow whole. Initially 500mg twice daily, may increase to max 1g twice daily. Concomitant moderate CYP3A inhibitors (eg, diltiazem, verapamil, erythromycin, fluconazole, grapefruit-containing products): max 500mg twice daily. Concomitant P-gp inhibitors (eg, cyclosporine): titrate ranolazine dose based on response. Concomitant simvastatin: limit simvastatin to 20mg once daily. Concomitant metformin: give max metformin 1.7g/day if taking ranolazine 1g twice daily.
Children
Not established.
Ranexa Contraindications
Contraindications
Liver cirrhosis. Concomitant strong CYP3A inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, saquinavir) or CYP3A inducers (eg, rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, St. John's wort).
Ranexa Boxed Warnings
Not Applicable
Ranexa Warnings/Precautions
Warnings/Precautions
Not for acute angina episodes or for treating diabetes. History of or congenital long QT syndrome. Monitor renal function after initiation and periodically in moderate to severe renal impairment. Discontinue if acute renal failure develops. Elderly. Pregnancy. Nursing mothers.
Ranexa Pharmacokinetics
See Literature
Ranexa Interactions
Interactions
See Contraindications. Potentiates metformin; monitor glucose levels. May potentiate drugs metabolized by CYP3A (eg, simvastatin, lovastatin, cyclosporine, tacrolimus, sirolimus), P-gp transporters (eg, digoxin), CYP2D6 (eg, antipsychotics, tricyclic antidepressants); adjust doses of these drugs. May be potentiated by P-gp inhibitors (eg, cyclosporine). Caution with drugs that cause QT prolongation (eg, Class IA, Class III antiarrhythmics, thioridazine, ziprasidone).
Ranexa Adverse Reactions
Adverse Reactions
Dizziness, headache, constipation, nausea; QT prolongation.
Ranexa Clinical Trials
See Literature
Ranexa Note
Not Applicable
Ranexa Patient Counseling
See Literature
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