Ranexa

— THERAPEUTIC DISORDERS TREATED —
  • Angina

Ranexa Generic Name & Formulations

General Description

Ranolazine 500mg, 1000mg; ext-rel tabs.

Pharmacological Class

Antianginal.

How Supplied

Tabs—60

Manufacturer

Ranexa Indications

Indications

Chronic angina; may be used with beta-blockers, nitrates, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, anti-platelet and lipid-lowering therapies.

Ranexa Dosage and Administration

Adult

Swallow whole. Initially 500mg twice daily, may increase to max 1g twice daily. Concomitant moderate CYP3A inhibitors (eg, diltiazem, verapamil, erythromycin, fluconazole, grapefruit-containing products): max 500mg twice daily. Concomitant P-gp inhibitors (eg, cyclosporine): titrate ranolazine dose based on response. Concomitant simvastatin: limit simvastatin to 20mg once daily. Concomitant metformin: give max metformin 1.7g/day if taking ranolazine 1g twice daily.

Children

Not established.

Ranexa Contraindications

Contraindications

Liver cirrhosis. Concomitant strong CYP3A inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, saquinavir) or CYP3A inducers (eg, rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, St. John's wort).

Ranexa Boxed Warnings

Not Applicable

Ranexa Warnings/Precautions

Warnings/Precautions

Not for acute angina episodes or for treating diabetes. History of or congenital long QT syndrome. Monitor renal function after initiation and periodically in moderate to severe renal impairment. Discontinue if acute renal failure develops. Elderly. Pregnancy. Nursing mothers.

Ranexa Pharmacokinetics

See Literature

Ranexa Interactions

Interactions

See Contraindications. Potentiates metformin; monitor glucose levels. May potentiate drugs metabolized by CYP3A (eg, simvastatin, lovastatin, cyclosporine, tacrolimus, sirolimus), P-gp transporters (eg, digoxin), CYP2D6 (eg, antipsychotics, tricyclic antidepressants); adjust doses of these drugs. May be potentiated by P-gp inhibitors (eg, cyclosporine). Caution with drugs that cause QT prolongation (eg, Class IA, Class III antiarrhythmics, thioridazine, ziprasidone).

Ranexa Adverse Reactions

Adverse Reactions

Dizziness, headache, constipation, nausea; QT prolongation.

Ranexa Clinical Trials

See Literature

Ranexa Note

Not Applicable

Ranexa Patient Counseling

See Literature

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