Quinidine Gluconate

  • CHF and arrhythmias

Quinidine Gluconate Generic Name & Formulations

General Description

Quinidine gluconate 324mg; ext-rel tabs.

Pharmacological Class

Class I antiarrhythmic.

How Supplied

Contact supplier.

Quinidine Gluconate Indications


Atrial and ventricular arrhythmias (see full labeling).

Quinidine Gluconate Dosage and Administration


Take with fluid and in an upright position. Individualize. Prevention of premature atrial, nodal and ventricular contractions: 324–648mg every 8–12 hrs. Maintenance of sinus rhythm following cardioversion: 648mg every 12 hrs or 486–648mg every 8 hrs.


Not recommended.

Quinidine Gluconate Contraindications


Complete AV or bundle branch block or other severe intraventricular conduction defects. Myasthenia gravis. Digitalis intoxication. Aberrant impulses, abnormal rhythms due to escape mechanisms.

Quinidine Gluconate Boxed Warnings

Not Applicable

Quinidine Gluconate Warnings/Precautions


Atrial flutter; digitalize first. Incomplete AV block. Heart failure. Marginally compensated cardiovascular disease. Hypotension. Renal and hepatic dysfunction. Monitor blood, liver and kidney function in long-term use. Monitor ECG and serum levels if dose is over 2.5g/day. Pregnancy (Cat.C). Nursing mothers.

Quinidine Gluconate Pharmacokinetics

See Literature

Quinidine Gluconate Interactions


Quinidine toxicity increased by amiodarone, cimetidine, ranitidine, diuretics, carbonic anhydrase inhibitors, sodium bicarbonate, verapamil, diltiazem. Potentiates anticoagulants, anticholinergics, neuromuscular blocking agents, phenothiazines, reserpine, timolol. Increases digitalis serum levels. Quinidine levels decreased by barbiturates, hydantoins, rifampin, nifedipine.

Quinidine Gluconate Adverse Reactions

Adverse Reactions

Nausea, vomiting, abdominal pain, diarrhea, new or exacerbated arrhythmias, heart block, syncope, cinchonism, headache, blood dyscrasias, hypotension, flushing, allergic reactions, impaired hearing and vision, hepatic dysfunction.

Quinidine Gluconate Clinical Trials

See Literature

Quinidine Gluconate Note


Formerly known under the brand names Duraquin, Quinact, Quinaglute.

Quinidine Gluconate Patient Counseling

See Literature